{"id":23,"date":"2020-10-14T13:05:56","date_gmt":"2020-10-14T13:05:56","guid":{"rendered":"http:\/\/blogs.uakron.edu\/aaristot\/?page_id=23"},"modified":"2023-11-25T13:56:58","modified_gmt":"2023-11-25T13:56:58","slug":"research","status":"publish","type":"page","link":"https:\/\/blogs.uakron.edu\/aaristot\/research\/","title":{"rendered":"Research"},"content":{"rendered":"\n<div class=\"wp-block-image\">\r\n<figure><img loading=\"lazy\" decoding=\"async\" class=\"alignnone  wp-image-338 aligncenter\" src=\"https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2022\/09\/Andreas.jpg?w=278\" alt=\"\" width=\"296\" height=\"319\" srcset=\"https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2022\/09\/Andreas.jpg 296w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2022\/09\/Andreas.jpg?resize=278,300 278w\" sizes=\"auto, (max-width: 296px) 100vw, 296px\" \/><\/figure>\r\n<p>&nbsp;<\/p>\r\n<figure><\/figure>\r\n<figure class=\"aligncenter size-large\">My research interests are focused on the <em>development<\/em>, <em>theoretical analysis<\/em> and <em>implementation<\/em> of efficient algorithms in view of their application to the simulation of problems of practical interest. My specialty is on <a href=\"http:\/\/en.wikipedia.org\/wiki\/Discontinuous_Galerkin_method\" target=\"_blank\" rel=\"noreferrer noopener\">Discontinuous Galerkin Finite Element Methods<\/a> (DG-FE) methods for the numerical solution of partial differential equation (PDE) problems and applications. Specifically, I am interested in the development and analysis of high order numerical schemes that accurately and efficiently resolve the solution\u00a0to non linear equations like <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cahn%E2%80%93Hilliard_equation\" target=\"_blank\" rel=\"noreferrer noopener\">Cahn-Hilliard<\/a> type equations, arising in models describing biological growth e.g. <em>cancerous tumors<\/em> and phase separation. <a href=\"https:\/\/www.google.com\/search?q=triangular+adaptive+mesh+refinement&amp;client=firefox-a&amp;hs=cFg&amp;rls=org.mozilla:en-US:official&amp;channel=fflb&amp;tbm=isch&amp;tbo=u&amp;source=univ&amp;sa=X&amp;ei=4GLvU4GUN4j4yQTS04CgAg&amp;ved=0CEoQsAQ&amp;biw=1280&amp;bih=672\" target=\"_blank\" rel=\"noreferrer noopener\">Adaptive mesh refinement<\/a>, (theoretical) error analysis and energy stability via convex splitting are also being addressed in my work. For the solution of the resulting algebraic (nonlinear)\u00a0systems efficient solvers based on <a href=\"http:\/\/en.wikipedia.org\/wiki\/Multigrid_method\" target=\"_blank\" rel=\"noreferrer noopener\">multigrid<\/a> are designed. Recently the development and application of <em>machine learning methods<\/em> for the numerical solution of partial differential equations is an interesting aspect of my work.<\/figure>\r\n<\/div>\n\n\n\n<p>The development of <em>hybrid discrete cellular automata systems<\/em> (HD-CA) by coupling linear and non-linear reaction diffusion partial differential equations with discrete (stochastic) <a href=\"http:\/\/en.wikipedia.org\/wiki\/Cellular_automaton\" target=\"_blank\" rel=\"noreferrer noopener\">cellular automata<\/a> systems is also a part of my work. I utilize hybrid discrete systems to derive constitutive relationships and study phenomena in biology specifically <em>biofilm, cancer, tissue engineering, virus dynamics modeling<\/em>, and <em>evolutionary game theory<\/em>.<\/p>\n\n\n\n<p><em><strong>I am looking for motivated students with love for mathematics that are interested in doing research. Ask me for more details!!<\/strong><\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">\u00a0<\/h2>\r\n<h2>External Funding<\/h2>\r\n<ul>\r\n<li><em>As PI: 2017-2020,<\/em>\u00a0\u00a0NSF-DMS 1720226, <strong><em>Awarded<\/em>\u00a0$100,115.00<\/strong>,\u00a0Title:\u00a0&#8220;<em>Computational Methods for Heterogeneous Soft Living Materials&#8221; (<strong><a href=\"https:\/\/www.nsf.gov\/awardsearch\/showAward?AWD_ID=1720226&amp;HistoricalAwards=false\" target=\"_blank\" rel=\"noopener\">Link<\/a>)<\/strong><\/em><\/li>\r\n<\/ul>\r\n<h2>Current Research Projects<\/h2>\n\n\n\n\n\n<ul class=\"wp-block-list\" id=\"block-aef29901-4718-4326-a9bf-fd9c55a76b81\">\n<li>Discontinuous Galerkin Finite Element methods for the numerical solution of various Cahn-Hilliard type equations<br>Work involves development, convergence analysis (error estimates) and implementation of numerical schemes in primitive variable and mixed formulations, utilizing adaptive mesh refinement and fast linear and nonlinear system solvers.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>With Professor&#8217;s Vasileios Maroulas group, University of Tennessee Mathematics: Working on machine learning for PDEs.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>With Professor&#8217;s Gregory Forest group, UNC Mathematics: We are interested in modeling the SARS-CoV-2 progression in the respiratory track.<\/li>\n<\/ul>\n\n\n<h2>Publications<\/h2>\n<p><strong>Machine Learning for PDEs<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-382 aligncenter\" src=\"https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2023\/01\/res500_10point.jpg?w=300\" alt=\"\" width=\"204\" height=\"165\" srcset=\"https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2023\/01\/res500_10point.jpg 391w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2023\/01\/res500_10point.jpg?resize=300,244 300w\" sizes=\"auto, (max-width: 204px) 100vw, 204px\" \/><\/p>\n<p>\u00a0<\/p>\n<ul>\n<li>Aristotelous, A. C., Mitchell, E. C., Maroulas, V. (2023) ADLGM: An efficient adaptive sampling deep learning Galerkin method<i>, Journal of\u00a0Computational\u00a0Physics, 111944.\u00a0<\/i>(<a href=\"https:\/\/doi.org\/10.1016\/j.jcp.2023.111944\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<br \/><br \/><\/li>\n<li>Aristotelous, A. C. &amp; Papanicolaou, N. C. (2023) On the Transferability of the Deep Galerkin Method for Solving Partial Differential Equations.<br \/><em>American Institute of Physics (AIP) Conference Proceedings<\/em>, <em>2953<\/em>, 090001, (<a href=\"https:\/\/doi.org\/10.1063\/5.0177426\" target=\"_blank\" rel=\"noopener\">Link<\/a>).<\/li>\n<\/ul>\n\n\n<p><p>&nbsp;<\/p>\n<p><strong>Hybrid Discrete Systems<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-131 aligncenter\" src=\"https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/HD_systems_web.jpg?w=300\" alt=\"\" width=\"480\" height=\"219\" srcset=\"https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/HD_systems_web.jpg 845w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/HD_systems_web.jpg?resize=300,137 300w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/HD_systems_web.jpg?resize=768,351 768w\" sizes=\"auto, (max-width: 480px) 100vw, 480px\" \/><\/p>\n<p>&nbsp;<\/p><\/p>\n\n\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aristotelous, A. C., Chen, A., Forest, M. G. (2022) A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate response<em>, Journal of Theoretical Biology, 111293.&nbsp;<\/em>(<a href=\"https:\/\/doi.org\/10.1016\/j.jtbi.2022.111293\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<br><br><\/li>\n\n\n\n<li>Aristotelous, A. C. (2022) Biofilm neutrophils interactions under hypoxia: A mathematical modeling study. <em>Mathematical Biosciences, 352,<\/em> 108893. (<a href=\"https:\/\/doi.org\/10.1016\/j.mbs.2022.108893\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<br><br><\/li>\n\n\n\n<li>Aristotelous, A. C., Grabovsky, Y. &amp; Klapper, I. (2018) Heterogeneity Formation Within Biofilm Systems. <em>European Journal of Applied Mathematics,<\/em> 1-15. (<a href=\"https:\/\/www.cambridge.org\/core\/journals\/european-journal-of-applied-mathematics\/article\/heterogeneity-formation-within-biofilm-systems\/DC984AD0EE3E32ED3800788D6508391E\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aristotelous, A. C., Klapper, I., Grabovsky, Y., Pabst, B., Pitts, B. and Stewart, P. S. (2015) Diffusive Transport Through Host-Biofilm Systems.&nbsp;<em>Phys. Rev. E&nbsp;<\/em>, 92-2, 022703. (<a href=\"http:\/\/dx.doi.org\/10.1103\/PhysRevE.92.022703\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aristotelous, A. C. and Durrett, R. (2014) Fingering in Stochastic Growth Models.&nbsp;<em>Experimental Mathematics<\/em>, 23-4, 465&#8211;474. (<a href=\"http:\/\/dx.doi.org\/10.1080\/10586458.2014.947053\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aristotelous, A. C. and Haider, M. A. (2014) Evaluation of Diffusive Transport and Cellular Uptake of Nutrients in Tissue Engineered Constructs using a Hybrid Discrete Model.&nbsp;<em>Processes: Special Issue &#8220;Design of bioreactor systems for tissue engineering&#8221;<\/em>, 2-2, 333&#8211;344. (<a href=\"http:\/\/dx.doi.org\/10.3390\/pr2020333\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aristotelous, A. C. and Durrett, R. (2014) Chemical Evolutionary Games.&nbsp;<em>Theoretical Population Biology<\/em>, 93, 1&#8211;13. (<a href=\"http:\/\/dx.doi.org\/10.1016\/j.tpb.2014.02.001\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aristotelous, A. C. and Haider, M. A. (2014) Use of Hybrid Discrete Cellular Models for Identification of Macroscopic Nutrient Loss in Reaction-Diffusion Models of Tissues.&nbsp;<em>Int. J. Numer. Meth. Biomed. Engng.<\/em>, 30-8,767&#8211;780. (<a href=\"http:\/\/dx.doi.org\/10.1002\/cnm.2628\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<p>&nbsp;<\/p>\r\n<p><strong>Numerical Analysis<\/strong><\/p>\r\n<p>&nbsp;<\/p>\r\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-179 aligncenter\" src=\"https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/CH3D.png?w=300\" alt=\"\" width=\"182\" height=\"127\" srcset=\"https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/CH3D.png 1954w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/CH3D.png?resize=300,209 300w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/CH3D.png?resize=768,535 768w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/CH3D.png?resize=1024,714 1024w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/CH3D.png?resize=1536,1071 1536w\" sizes=\"auto, (max-width: 182px) 100vw, 182px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"wp-image-127 aligncenter\" src=\"https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/adaptive_growth.jpg?w=300\" alt=\"\" width=\"414\" height=\"123\" srcset=\"https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/adaptive_growth.jpg 1946w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/adaptive_growth.jpg?resize=300,90 300w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/adaptive_growth.jpg?resize=768,230 768w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/adaptive_growth.jpg?resize=1024,306 1024w, https:\/\/blogs.uakron.edu\/aaristot\/wp-content\/uploads\/sites\/1615\/2020\/10\/adaptive_growth.jpg?resize=1536,459 1536w\" sizes=\"auto, (max-width: 414px) 100vw, 414px\" \/><\/p>\r\n<p>&nbsp;<\/p>\r\n<p>\n\n\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aristotelous, A. C. (2023) Energy Stable Symmetric Interior Penalty Discontinuous\u00a0Galerkin Finite Element for a Growth Cahn-Hilliard Equation. <br><em>American Institute of Physics (AIP) Conference Proceedings<\/em>, <em>2953<\/em>, 080001 (<a href=\"https:\/\/doi.org\/10.1063\/5.0177573\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>).<br><br><\/li>\n\n\n\n<li>Aristotelous, A. C., Karakashian, O. A. and Wise, S. M. (2015) Adaptive, Second-Order in Time, Primitive-Variable Discontinuous Galerkin Schemes for a Cahn-Hilliard Equation with a Mass Source.&nbsp;<em>IMA J. Numer. Anal.<\/em>, 35-3, 1167&#8211;1198. (<a href=\"http:\/\/imajna.oxfordjournals.org\/content\/35\/3\/1167\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<\/p>\r\n<ul class=\"wp-block-list\">\r\n<li>Aristotelous, A. C., Karakashian, O. A. and Wise, S. M. (2013) A Mixed Discontinuous Galerkin, Convex Splitting Scheme for a Modified Cahn-Hilliard Equation and an Efficient Nonlinear Multigrid Solver.\u00a0<em>DCDS-B<\/em>, 18-9, 2211&#8211;2238. (<a href=\"https:\/\/www.aimsciences.org\/journals\/displayArticles.jsp?paperID=8984\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\r\n<\/ul>\r\n<p>&nbsp;<\/p>\r\n<p><strong>Computational Models<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A. C. Aristotelous &amp; N. C. Papanicolaou (2017) A Numerical Study of Biofilm Growth in a Microgravity Environment. <em>American Institute of Physics (AIP) Conference Proceedings, 1895<\/em>, 120001. (<a href=\"http:\/\/aip.scitation.org\/doi\/abs\/10.1063\/1.5007418\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<p><p>&nbsp;<\/p>\n<p><strong>Computational Fluid Dynamics<\/strong><\/p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aristotelous, A. C. &amp; Papanicolaou, N. C. (2016) A Discontinuous Galerkin Method for Unsteady Two-dimensional Convective Flows. <em>American Institute of Physics (AIP) Conference Proceedings, 1773<\/em>, 110002. (<a href=\"http:\/\/aip.scitation.org\/doi\/abs\/10.1063\/1.4965006\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Papanicolaou, N. C. and Aristotelous, A. C. (2015) High-Order Discontinuous Galerkin Methods for Coupled Thermoconvective Flows under Gravity Modulation.&nbsp;<em>American Institute of Physics (AIP) Conference Proceedings 1684.<\/em>, 090010. (<a href=\"http:\/\/dx.doi.org\/10.1063\/1.4934335\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<p><p>&nbsp;<\/p>\n<p><strong>Review Papers<\/strong><\/p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aristotelous, A. C., Crawford, J. M., Edwards, G. S., Kiehart, D. P. &amp; Venakides, S. (2018) Mathematical models of dorsal closure. <em>Progress in Biophysics and Molecular Biology,&nbsp; <\/em>137, 111&#8211;131 (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S007961071830021X?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Daniel P. Kiehart, Janice M. Crawford, Andreas C. Aristotelous, Stephanos Venakides &amp; Glenn S. Edwards (2017) Cell Sheet Morphogenesis: Dorsal Closure in Drosophila Melanogaster as a Model System. <em>Annual Review of Cellular and Developmental Biology, 33-1<\/em>, 169&#8211;202. (<a href=\"http:\/\/www.annualreviews.org\/doi\/abs\/10.1146\/annurev-cellbio-111315-125357?af=R\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n\n\n\n<p><p>&nbsp;<\/p>\n<p><strong>PhD Dissertation<\/strong><\/p><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aristotelous, A. C. (2011) Adaptive Discontinuous Galerkin Finite Element Methods for a Diffuse Interface Model of Biological Growth.&nbsp;<em>PhD Thesis<\/em>, The University of Tennessee, U.S.A. (<a href=\"http:\/\/trace.tennessee.edu\/utk_graddiss\/1051\/\" target=\"_blank\" rel=\"noreferrer noopener\">Link<\/a>)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The development of hybrid discrete cellular automata systems (HD-CA) by coupling linear and non-linear reaction diffusion partial differential equations with discrete (stochastic) cellular automata systems is also a part of my work. I utilize hybrid discrete systems to derive constitutive relationships and study phenomena in biology specifically biofilm, cancer, tissue engineering, virus dynamics modeling, and [&hellip;]<\/p>\n","protected":false},"author":4519,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-23","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/blogs.uakron.edu\/aaristot\/wp-json\/wp\/v2\/pages\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.uakron.edu\/aaristot\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.uakron.edu\/aaristot\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.uakron.edu\/aaristot\/wp-json\/wp\/v2\/users\/4519"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.uakron.edu\/aaristot\/wp-json\/wp\/v2\/comments?post=23"}],"version-history":[{"count":51,"href":"https:\/\/blogs.uakron.edu\/aaristot\/wp-json\/wp\/v2\/pages\/23\/revisions"}],"predecessor-version":[{"id":413,"href":"https:\/\/blogs.uakron.edu\/aaristot\/wp-json\/wp\/v2\/pages\/23\/revisions\/413"}],"wp:attachment":[{"href":"https:\/\/blogs.uakron.edu\/aaristot\/wp-json\/wp\/v2\/media?parent=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}