{"id":43411,"date":"2020-02-18T14:54:47","date_gmt":"2020-02-18T19:54:47","guid":{"rendered":"http:\/\/blogs.uakron.edu\/researchnewsinfo\/?p=43411"},"modified":"2020-02-18T14:56:02","modified_gmt":"2020-02-18T19:56:02","slug":"notice-of-special-interest-nosi-to-highlight-research-priorities-for-risk-algorithms-applications-in-healthcare-settings-to-improve-suicide-prevention","status":"publish","type":"post","link":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/2020\/02\/18\/notice-of-special-interest-nosi-to-highlight-research-priorities-for-risk-algorithms-applications-in-healthcare-settings-to-improve-suicide-prevention\/","title":{"rendered":"Notice of Special Interest (NOSI) to Highlight Research Priorities for Risk Algorithms Applications in Healthcare Settings to Improve Suicide Prevention"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/blogs.uakron.edu\/researchnewsinfo\/files\/2020\/02\/NIH-logo.jpg\" alt=\"\" class=\"wp-image-43415\" width=\"365\" height=\"130\" srcset=\"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-content\/uploads\/sites\/871\/2020\/02\/NIH-logo.jpg 600w, https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-content\/uploads\/sites\/871\/2020\/02\/NIH-logo.jpg?resize=300,108 300w, https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-content\/uploads\/sites\/871\/2020\/02\/NIH-logo.jpg?resize=500,180 500w\" sizes=\"auto, (max-width: 365px) 100vw, 365px\" \/><\/figure><\/div>\n\n\n\n<p>Notice Number: \nNOT-MH-20-031<\/p>\n\n\n\n<p>Key Dates<br><strong>Release Date:<\/strong> February 14, 2020<br><strong>First Available Due Date:<\/strong> June 05, 2020 <br><strong>Expiration Date: <\/strong>January 08, 2022 Related Announcements<br> <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PAR-19-189.html\" target=\"_blank\">PAR-19-189<\/a>, Pilot Services Research Grants Not Involving Clinical Trials (R34 Clinical Trial Not Allowed)<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/par-17-264.html\" target=\"_blank\">PAR-17-264<\/a>, Innovative Mental Health Services Research Not Involving Clinical Trials (R01)<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PA-19-056.html\" target=\"_blank\">PA-19-056<\/a>, NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/pa-19-055.html\" target=\"_blank\">PA-19-055<\/a>, Research Project Grant (Parent R01 Clinical Trial Required)<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/pa-18-350.html\" target=\"_blank\">PA-18-350<\/a>, NIMH Exploratory\/Developmental Research Grant (R21 Clinical Trial Not Allowed)<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PA-19-052.html\" target=\"_blank\">PA-19-052<\/a>, NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-18-700.html\" target=\"_blank\">RFA-MH-18-700<\/a>,  Clinical Trials to Test the Effectiveness of Treatment, Preventive, and  Services Interventions (Collaborative R01 &#8211; Clinical Trial Required)<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/RFA-MH-18-701.html\" target=\"_blank\">RFA-MH-18-701<\/a>, Clinical Trials to Test the Effectiveness of Treatment, Preventive, and Services Interventions (R01 Clinical Trial Required)<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/rfa-mh-18-706.html\" target=\"_blank\">RFA-MH-18-706<\/a>, Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R34- Clinical Trial Required)<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PAR-18-929.html\" target=\"_blank\">PAR-18-929<\/a>, High-Priority Areas for Research Leveraging EHR and Large-Scale Data (R01 Clinical Trial Not Allowed)<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/pa-18-566.html\" target=\"_blank\">PA-18-566<\/a>&nbsp;Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R43\/R44 Clinical Trial Optional) <\/p>\n\n\n\n<p>Issued by National Institute of Mental Health (<a rel=\"noreferrer noopener\" href=\"https:\/\/www.nimh.nih.gov\/index.shtml\" target=\"_blank\">NIMH<\/a>)<br><\/p>\n\n\n\n<p><strong>Purpose<\/strong><\/p>\n\n\n\n<p>Risk identification is a key component of suicide prevention. In healthcare settings, current risk identification is typically obtained through patients\u2019 endorsement of items on screeners, either administered by a clinician or completed by patients through a tablet or via paper\/pencil. Another way to identify people with suicide risk is via risk algorithms based on medical record data, which can be considered complementary to the traditional screening associated with clinical encounters in several ways: 1) it does not rely on people to answer questions, it looks at what they have done as opposed to what they say;  2) you can look across a panel of people &#8211; not just those seen in face-to-face healthcare contacts.<\/p>\n\n\n\n<p>Risk algorithms have been shown in multiple settings to be a validated way to identify individuals with high suicide risk who warrant additional clinical attention. To date, risk algorithm approaches have not been designed to predict outcomes for individual patients, but rather to assign people into differential tiers of risk. The use of these tools presents some special challenges, including issues around logistics, ethics, and acceptability, and each of these areas present research gaps.<\/p>\n\n\n\n<p>NIMH held a meeting in June 2019 to identify and prioritize research needs in the application of predictive analytics in suicide prevention among healthcare providers. The meeting summary details  research topics and gaps that included: biostatistical challenges, provider and patient understanding of risk algorithms, ethical considerations, needs for clinical decision tools to guide risk algorithm application, and policy-relevant research. NIMH is encouraging practice and deployment relevant applications proposed by  multidisciplinary teams addressing the following topics:<\/p>\n\n\n\n<p><strong>Biostatistical Challenges:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Test approaches that could lead to:       <ul><li>Identifying best practices in the design of the cohorts used to develop risk algorithms, to ensure that the design is suitable for the purpose(s) for which the algorithm is being utilized.<\/li><li>Identifying best practices in assessing the performance of suicide risk algorithms \u2013 including possible effects on equity in treatment and outcomes.     <\/li><\/ul><\/li><li>Examine the benefits and limitations of risk algorithms that consider multiple or composite outcomes, such as risk for non-fatal as well as fatal suicide events, fatal and non-fatal accidents, and others.<\/li><li>Examine the benefits and limitations of developing and operating multiple risk algorithms for specific subgroups within a larger population\/cohort (e.g., those with certain characteristics or experiences, or in certain geographic or care settings), versus one algorithm that is used with the entire population\/cohort.<\/li><li>Develop and test criteria to determine when it might be appropriate to use an algorithm developed in one setting or population\/cohort and apply it in a different setting or population\/cohort (e.g. if health system B uses an algorithm developed  and validated by health system A); versus developing and validating algorithms for each specific setting or population\/cohort that seeks to use this approach.<\/li><li>Compare risk modeling benefits and challenges over alternative time periods, e.g., outcomes within 1 vs. 3 vs. 12 months. For example, if long time periods take place between algorithm calculations, at what point are the outcomes \u2018stale\u2019 and less clinically useful?<\/li><li>Explore whether risk algorithms preserve or \u2013 worse \u2013  potentially expand disparities in treatment and outcomes; and, if so, develop possible methods to mitigate this.<\/li><li>What are special considerations for developing risk algorithms for smaller subgroups (e.g., historically disadvantaged groups, sexual minorities, age groups, etc.), such as longer time frames needed and prediction utility?<\/li><li>Examine the relationships between absolute (predicted) risk, on the one hand, and how identified patients may respond to intervention, on the other. Assess the potential added value of drawing on various types of data in developing risk algorithms, e.g., structured measures from health care claims\/encounters and electronic health records, patient-reported measures, measures derived via abstraction or natural  language processing from patient care records, measures derived from passive sensor monitoring (e.g., via smartphone); as well as the value  of data derived from outside healthcare (e.g., social media, public records, and commercially available data such as credit information, among others).<\/li><\/ul>\n\n\n\n<p><strong>Provider Understanding, Acceptance and Use of Results from Suicide Risk Algorithms:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>What clinical decision-making data and practical approaches facilitate deciding which risk model to use; what risk strata to intervene on, and how to intervene?<\/li><li>How could information on potential patient responses to targeted clinical interventions affect how risk algorithm models are developed, and how they are used (e.g., will patients engage in the interventions offered; what are rates of response to the intervention)?<\/li><li>What are useful approaches to determining when a risk indicator be \u2018turned off\u2019 (e.g., indicators of \u2018recovery\u2019)<\/li><\/ul>\n\n\n\n<p><em><strong>Patient Understanding and Acceptance of Results from Suicide Risk Algorithms, and Ethical Concerns (see also&nbsp;<\/strong><\/em><a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/notice-files\/NOT-OD-20-038.html\" target=\"_blank\"><strong>NOT-OD-20-038<\/strong><\/a><em><strong>)<\/strong><\/em><\/p>\n\n\n\n<p> Research is needed that tests approaches to educating patients about risk categories and how clinical care and personal actions may change risk status, with implications for developing healthcare setting best practices in applying risk algorithms to care. When and how are informed consent processes needed when using suicide risk algorithms in practice? Should risk algorithm outcomes be considered PHI for purposed of HIPAA? Practically, how would risk algorithm outcomes be provided in patient portal access (e.g., as a test result with interpretation)? How can patients\u2019 family members\/designated significant others, be informed of a patients\u2019 increased risk? Under what circumstances do patients see algorithm use as \u2018intrusive,\u2019 or inaccurate (where they may be perpetuating disparities in healthcare services), and what are potential remedies to address these problems?<\/p>\n\n\n\n<p>All requirements of the relevant FOA would need to be followed in any application (and award) that proposes to develop and conduct a study on one of these high priority areas. Possible funding opportunities that can be used to pursue these and other research activities include the following FOAs and any re-issuances of these FOAs through the  expiration date of this notice. Please note that investigators interested in pursuing clinical  trial research should review the NIMH Clinical Trials Funding Opportunity Announcements <a href=\"http:\/\/www.nimh.nih.gov\/funding\/opportunities-announcements\/clinical-trials-foas\/index.shtml\">Website.<\/a><\/p>\n\n\n\n<p>Investigators seeking National Death Index Linkage should review&nbsp;<a href=\"https:\/\/grants.nih.gov\/grants\/guide\/notice-files\/NOT-OD-20-057.html\" target=\"_blank\" rel=\"noreferrer noopener\">NOT-OD-20-057<\/a>, National Death Index Linkage Access for NIH-Supported Investigators.<\/p>\n\n\n\n<p>Applicants considering such an application are strongly encouraged to consult with NIMH Program Officials prior to submission.<\/p>\n\n\n\n<p><strong>Application and Submission Information<\/strong><\/p>\n\n\n\n<p>This notice applies to due dates on or after June 5, 2020 and subsequent receipt dates through September 8, 2022.<\/p>\n\n\n\n<p>Submit applications for this initiative using one of the following  funding opportunity announcements (FOAs) or any reissues of these announcement through the expiration date of this notice.<\/p>\n\n\n\n<p>R34 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PAR-19-189.html\" target=\"_blank\">PAR-19-189, Pilot Services Research Grants Not Involving Clinical Trials (R34-Clinical Trial Not Allowed)<\/a> &#8211; First Available Due Date 06\/16\/2020<\/p>\n\n\n\n<p>R01 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/par-17-264.html\" target=\"_blank\">PAR-17-264, Innovative Mental Health Services Research Not Involving Clinical Trials (R01)<\/a> &#8211; First Available Due Date 06\/05\/2020<\/p>\n\n\n\n<p>R01 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/par-18-929.html\" target=\"_blank\">PAR-18-929, High-Priority Areas for Research Leveraging EHR and Large-Scale Data (R01-Clinical Trial Not Allowed)<\/a> &#8211; First Available Due Date 06\/05\/2020<\/p>\n\n\n\n<p>R01 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PA-19-056.html\" target=\"_blank\">PA-19-056, NIH Research Project Grant (Parent R01-Clinical Trial Not Allowed)<\/a> &#8211; First Available Due Date 06\/05\/2020<\/p>\n\n\n\n<p>R01 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/pa-19-055.html\" target=\"_blank\">PA-19-055, Research Project Grant (Parent R01-Clinical Trial Required)<\/a> &#8211; First Available Due Date 06\/05\/2020<\/p>\n\n\n\n<p>R21 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/pa-18-350.html\" target=\"_blank\">PA-18-350,&nbsp;NIMH Exploratory\/Developmental Research Grant (R21-Clinical Trial Not Allowed)<\/a> &#8211; First Available Due Date 06\/16\/2020<\/p>\n\n\n\n<p>R03 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/pa-files\/PA-19-052.html\" target=\"_blank\">PA-19-052, NIH Small Research Grant Program (Parent R03- Clinical Trial Not Allowed)<\/a> &#8211; First Available Due Date 06\/16\/2020<\/p>\n\n\n\n<p>R34 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/rfa-mh-18-706.html\" target=\"_blank\">RFA-MH-18-706, Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R34-Clinical Trial Required)<\/a> &#8211; First Available Due Date 06\/15\/2020<\/p>\n\n\n\n<p>R01 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/rfa-mh-18-701.html\" target=\"_blank\">RFA-MH-18-701, Clinical Trials to Test the Effectiveness of Treatment, Preventive, &amp; Services Interventions (R01-Clinical Trial Required)<\/a> &#8211; First Available Due Date 06\/15\/2020<\/p>\n\n\n\n<p> R01 &#8211; <a rel=\"noreferrer noopener\" href=\"https:\/\/grants.nih.gov\/grants\/guide\/rfa-files\/rfa-mh-18-700.html\" target=\"_blank\">RFA-MH-18-700, Clinical Trials to Test the Effectiveness of Treatment, Preventive, &amp; Services Interventions (Collaborative R01-Clinical Trial Required)<\/a> &#8211; First Available Due Date 06\/15\/2020<\/p>\n\n\n\n<p>All instructions in the&nbsp;<a href=\"https:\/\/grants.nih.gov\/grants\/how-to-apply-application-guide.html\" target=\"_blank\" rel=\"noreferrer noopener\">SF424 (R&amp;R) Application Guide<\/a>&nbsp;and the funding opportunity announcement used for submission must be followed, with the following additions:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For funding consideration, applicants must include \u201cNOT-MH-20-031\u201d (without quotation marks) in the Agency Routing Identifier field (box 4B) of the SF424 R&amp;R form. Applications without this information in box 4B will not be considered for this  initiative.<\/li><\/ul>\n\n\n\n<p>Applications non-responsive to terms of this NOSI will be not be considered for the NOSI initiative. <\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"https:\/\/grants.nih.gov\/grants\/guide\/notice-files\/NOT-MH-20-031.html\"><img loading=\"lazy\" decoding=\"async\" width=\"173\" height=\"40\" src=\"http:\/\/blogs.uakron.edu\/researchnewsinfo\/files\/2020\/01\/Learn-More.jpg\" alt=\"\" class=\"wp-image-43111\" \/><\/a><\/figure><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Notice Number: NOT-MH-20-031 Key DatesRelease Date: February 14, 2020First Available Due Date: June 05, 2020 Expiration Date: January 08, 2022 Related Announcements PAR-19-189, Pilot Services Research Grants Not Involving Clinical Trials (R34 Clinical Trial Not Allowed) PAR-17-264, Innovative Mental Health &hellip; <a href=\"https:\/\/blogs.uakron.edu\/researchnewsinfo\/2020\/02\/18\/notice-of-special-interest-nosi-to-highlight-research-priorities-for-risk-algorithms-applications-in-healthcare-settings-to-improve-suicide-prevention\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":4195,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[185,49266,56250,56246,21023],"tags":[24893,47922,112407,21081,26462],"class_list":["post-43411","post","type-post","status-publish","format-standard","hentry","category-announcements","category-applied-science-and-technology","category-engineering-technology","category-healthbiomedical-research","category-science-and-engineering-funding-opportunities","tag-assessment","tag-clinical-trials","tag-electronic-health-records","tag-nih","tag-suicide-prevention"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/posts\/43411","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/users\/4195"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/comments?post=43411"}],"version-history":[{"count":5,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/posts\/43411\/revisions"}],"predecessor-version":[{"id":43435,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/posts\/43411\/revisions\/43435"}],"wp:attachment":[{"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/media?parent=43411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/categories?post=43411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/tags?post=43411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}