{"id":44591,"date":"2020-05-27T10:27:03","date_gmt":"2020-05-27T14:27:03","guid":{"rendered":"http:\/\/blogs.uakron.edu\/researchnewsinfo\/?p=44591"},"modified":"2020-05-27T10:27:03","modified_gmt":"2020-05-27T14:27:03","slug":"notice-of-special-interest-nosi-select-research-areas-for-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-and-coronavirus-disease-2019-covid-19","status":"publish","type":"post","link":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/2020\/05\/27\/notice-of-special-interest-nosi-select-research-areas-for-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-and-coronavirus-disease-2019-covid-19\/","title":{"rendered":"Notice of Special Interest (NOSI): Select Research Areas for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Coronavirus Disease 2019 (COVID-19)"},"content":{"rendered":"\n<div class=\"wp-block-image\"><figure class=\"aligncenter is-resized\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/blogs.uakron.edu\/researchnewsinfo\/files\/2020\/02\/NIH-logo.jpg\" alt=\"\" class=\"wp-image-43415\" width=\"251\" height=\"88\" \/><\/figure><\/div>\n\n\n\n<p>Coronaviruses are a diverse family of viruses that cause a range of disease in humans and animals, and there are currently no approved coronavirus vaccines or therapeutics. In January 2020, a novel coronavirus was identified as the causative agent of a global  pandemic of viral pneumonia. Current information regarding confirmed cases is changing daily and can be found on the Centers for Disease Control and Prevention website (<a rel=\"noreferrer noopener\" href=\"https:\/\/www.cdc.gov\/coronavirus\/index.html\" target=\"_blank\">https:\/\/www.cdc.gov\/coronavirus\/index.html<\/a>) and through other sources. Transmission characteristics and the associated morbidity and mortality are not completely understood, but there is clear evidence of human-to-human transmission. Many other aspects of viral pathogenesis, natural history, and host range are poorly understood. Given this, there is an urgent public health need to better understand the SARS-CoV-2\/COVID-19.<\/p>\n\n\n\n<p>In order to rapidly improve our understanding and available control measures for SARS-CoV-2 and COVID-19, NIAID is encouraging the submission of applications to address the following research areas of interest:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Studies to understand critical aspects of viral infection, replication, pathogenesis, and transmission<\/li><li>Studies on the evolution and emergence of SARS-CoV-2 viruses including the identification of factors that affect viral host-range and virulence<\/li><li>Development of sensitive, specific, and rapid clinical diagnostic tests for SARS-CoV-2<\/li><li>Development of SARS-COV-2 therapeutic candidates, especially broad-spectrum therapeutics against multiple coronavirus strains<\/li><li>Identification and evaluation of the innate, cellular and humoral immune responses to SARS-CoV-2 infection, including, but not limited to: cross-reactive antibodies from  individuals exposed to SARS-CoV-2 and other coronaviruses; viral epitopes critical for T-cell activation or antibody binding and neutralization; immune-mediated pathology or host factors that might predispose to severe infection; and studies to examine duration of protection or the potential for reinfection<\/li><li>Development of SARS-CoV-2 vaccine candidates, including approaches for pan-coronavirus protection, that include emerging antigen design strategies, novel platforms or delivery approaches, adjuvants, or assessing cross-neutralization potential of SARS-CoV vaccine candidates.<\/li><\/ul>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"aligncenter\"><a href=\"https:\/\/grants.nih.gov\/grants\/guide\/notice-files\/NOT-AI-20-051.html\"><img loading=\"lazy\" decoding=\"async\" width=\"173\" height=\"40\" src=\"http:\/\/blogs.uakron.edu\/researchnewsinfo\/files\/2020\/01\/Learn-More.jpg\" alt=\"\" class=\"wp-image-43111\" \/><\/a><\/figure><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Coronaviruses are a diverse family of viruses that cause a range of disease in humans and animals, and there are currently no approved coronavirus vaccines or therapeutics. In January 2020, a novel coronavirus was identified as the causative agent of &hellip; <a href=\"https:\/\/blogs.uakron.edu\/researchnewsinfo\/2020\/05\/27\/notice-of-special-interest-nosi-select-research-areas-for-severe-acute-respiratory-syndrome-coronavirus-2-sars-cov-2-and-coronavirus-disease-2019-covid-19\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":4195,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-44591","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/posts\/44591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/users\/4195"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/comments?post=44591"}],"version-history":[{"count":1,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/posts\/44591\/revisions"}],"predecessor-version":[{"id":44595,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/posts\/44591\/revisions\/44595"}],"wp:attachment":[{"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/media?parent=44591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/categories?post=44591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.uakron.edu\/researchnewsinfo\/wp-json\/wp\/v2\/tags?post=44591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}