{"id":4787,"date":"2021-03-31T18:13:55","date_gmt":"2021-03-31T18:13:55","guid":{"rendered":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/?p=4787"},"modified":"2022-10-07T18:14:28","modified_gmt":"2022-10-07T18:14:28","slug":"lipid-modulation-of-membrane-protein-properties","status":"publish","type":"post","link":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/2021\/03\/31\/lipid-modulation-of-membrane-protein-properties\/","title":{"rendered":"Lipid modulation of membrane protein properties"},"content":{"rendered":"\r\n<h3 class=\"wp-block-heading\" style=\"text-align: center\"><span style=\"color: #ff0000\">[Past Projects]<\/span><\/h3>\r\n<h3>Dr. Adam Smith and Grant Gilmore<\/h3>\r\n\r\n\r\n\r\n\r\n<hr class=\"wp-block-separator\" \/>\r\n\r\n\r\n\r\n\r\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1000\" height=\"483\" class=\"wp-image-3707\" src=\"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-content\/uploads\/sites\/1447\/2021\/03\/Smith1.jpg\" alt=\"\" srcset=\"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-content\/uploads\/sites\/1447\/2021\/03\/Smith1.jpg 1000w, https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-content\/uploads\/sites\/1447\/2021\/03\/Smith1.jpg?resize=300,145 300w, https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-content\/uploads\/sites\/1447\/2021\/03\/Smith1.jpg?resize=768,371 768w\" sizes=\"auto, (max-width: 1000px) 100vw, 1000px\" \/><\/figure>\r\n\r\n\r\n\r\n\r\nHuman cells produce hundreds of different lipid species, and the lipid complements of even closely related cells are diverse. Membrane lipid compositions are also highly susceptible to external inputs, especially cholesterol, polyunsaturated fatty acids (PUFAs), and gangliosides. In animal models, deprivation of \u03c9-3 PUFAs leads to neurodevelopmental deficits in the offspring. However, the biomolecular connection between lipid composition and cellular function is not well-understood. In this project the student will conduct experiments to determine how lipid content is coupled to membrane protein function. Cultured cells will be supplemented with different lipid inputs, and the effects on membrane proteins will be measured using quantitative biophysical methods. This project is part of a collaborative research grant focused on neurological pathologies associated with brain lipid composition.\r\n\r\n\r\n\r\n\r\n\r\n<hr class=\"wp-block-separator\" \/>\r\n\r\n\r\n\r\n\r\n\r\n<a href=\"https:\/\/smithlab.uakron.edu\/\">Click here to find out more about Dr. Smith&#8217;s research.<\/a>","protected":false},"excerpt":{"rendered":"<p>[Past Projects] Dr. Adam Smith and Grant Gilmore Human cells produce hundreds of different lipid species, and the lipid complements of even closely related cells are diverse. Membrane lipid compositions are also highly susceptible to external inputs, especially cholesterol, polyunsaturated fatty acids (PUFAs), and gangliosides. In animal models, deprivation of \u03c9-3 PUFAs leads to neurodevelopmental &hellip; <a href=\"https:\/\/blogs.uakron.edu\/tiered-mentoring\/2021\/03\/31\/lipid-modulation-of-membrane-protein-properties\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Lipid modulation of membrane protein properties<\/span><\/a><\/p>\n","protected":false},"author":4695,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[125789],"tags":[],"class_list":["post-4787","post","type-post","status-publish","format-standard","hentry","category-past-projects"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/posts\/4787","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/users\/4695"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/comments?post=4787"}],"version-history":[{"count":1,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/posts\/4787\/revisions"}],"predecessor-version":[{"id":4788,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/posts\/4787\/revisions\/4788"}],"wp:attachment":[{"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/media?parent=4787"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/categories?post=4787"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/tags?post=4787"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}