{"id":4799,"date":"2018-02-26T18:27:53","date_gmt":"2018-02-26T18:27:53","guid":{"rendered":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/?p=4799"},"modified":"2022-10-07T18:28:56","modified_gmt":"2022-10-07T18:28:56","slug":"hormone-signaling-and-fat-metabolism-genetically-modified-zebrafish","status":"publish","type":"post","link":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/2018\/02\/26\/hormone-signaling-and-fat-metabolism-genetically-modified-zebrafish\/","title":{"rendered":"Hormone signaling and fat metabolism: Genetically modified zebrafish"},"content":{"rendered":"<h3 style=\"text-align: center\"><span style=\"color: #ff0000\">[Past Projects]<\/span><\/h3>\n<h2>Dr. Richard Londraville and Matthew Tuttle<\/h2>\n<hr \/>\n<p>Human leptin is a hormone made in and secreted from white adipocytes (fat cells).\u00a0 The leptin signaling pathway mobilizes lipids for breakdown and suppresses appetite. \u00a0In mammals, congenital mutations in the DNA sequences of leptin signaling genes cause early-onset and morbid obesity, diabetes, and imbalanced energy homeostasis.\u00a0 Moreover, leptin is conserved throughout all major vertebrate clades \u2013 reptiles, birds, fishes, mammals, and amphibians.\u00a0 Using the zebrafish leptin signaling pathway as a model, our group specializes in comparative biology and molecular endocrinology.\u00a0 The incumbent will perform tasks related to zebrafish aquaculture, embryonic microinjection, and gene\/protein expression.\u00a0 Using the CRISPR\/Cas9 genome editing system, the project goal is to produce lines of genetically modified zebrafish with conditional knockouts in hormone signaling pathways involved in adipocyte metabolism.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-839\" src=\"http:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-content\/uploads\/sites\/1447\/2018\/02\/Tuttle-TIERED-MENTORING-IMG-300x97.jpg\" alt=\"\" width=\"756\" height=\"244\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><a href=\"http:\/\/blogs.uakron.edu\/londraville\/\">Click here for more information on Dr. Londraville&#8217;s lab.<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[Past Projects] Dr. Richard Londraville and Matthew Tuttle Human leptin is a hormone made in and secreted from white adipocytes (fat cells).\u00a0 The leptin signaling pathway mobilizes lipids for breakdown and suppresses appetite. \u00a0In mammals, congenital mutations in the DNA sequences of leptin signaling genes cause early-onset and morbid obesity, diabetes, and imbalanced energy homeostasis.\u00a0 &hellip; <a href=\"https:\/\/blogs.uakron.edu\/tiered-mentoring\/2018\/02\/26\/hormone-signaling-and-fat-metabolism-genetically-modified-zebrafish\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Hormone signaling and fat metabolism: Genetically modified zebrafish<\/span><\/a><\/p>\n","protected":false},"author":4695,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[125789],"tags":[],"class_list":["post-4799","post","type-post","status-publish","format-standard","hentry","category-past-projects"],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/posts\/4799","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/users\/4695"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/comments?post=4799"}],"version-history":[{"count":1,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/posts\/4799\/revisions"}],"predecessor-version":[{"id":4800,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/posts\/4799\/revisions\/4800"}],"wp:attachment":[{"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/media?parent=4799"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/categories?post=4799"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.uakron.edu\/tiered-mentoring\/wp-json\/wp\/v2\/tags?post=4799"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}