University of Akron

• P. Lybrook, H. Chen, E. Barna, J. Brown, A. Wong, J. Ketchum, G. Zhang, J. Zhe. “In situ detection of dead cells from live cells via a DC plus low frequency AC resistive pulse sensor“, Biomed Microdevices 28, 11 (2026), DOI: https://doi.org/10.1007/s10544-026-00797-y

• H. Chen, J. Brown, G. Zhang*, J. Zhe*. “High sensitivity detection of biotinylated molecules using a high-resolution resistive pulse sensor“, Nanoscale, 2025, 17, 27900-27910, DOI: https://doi.org/10.1039/d5nr03922c

• J. Xu, J. Brown, R. Shaik, L.Soto-Garcia, J. Liao, K. Nguyen, G. Zhang*, Yi Hong*. “Injectable myocardium-derived hydrogels with SDF-1α releasing for cardiac repair”, Biomaterials Advances, 2025, Volume 170,214203, DOI: 10.1016/j.bioadv.2025.214203

• H. Chen, J. Brown, A. Urban, G. Zhang, J.  Zhe. “Continuous Viscoelasticity Measurement of Cell Spheroids via Microfluidic Electrical Aspiration” ACS Sensors, 2024, 9 (11), 5875-5884, DOI: 10.1021/acssensors.4c01405

• R. Shaik, J. Brown, J. Xu, R. Lamichhane, Y. Wang, Y Hong, G. Zhang. “Cardiac Matrix-Derived Granular Hydrogel Enhances Cell Function in 3D Culture” ACS Applied Materials & Interfaces, 2024 16 (43), 58346-58356, DOI: 10.1021/acsami.4c12871

• S. Liu, M. Yang. C. Smarr, G Zhang, H. Barton, W.Xu. “Engineered Living Structures with Shape-Morphing Capability Enabled by 4D Printing with Functional Bacteria”, ACS Applied Bio Materials, 2024, 7, 5, 3247–3257, DOI: 10.1021/acsabm.4c00223

• L.Ouyang, H. Chen. R. Xu,R. Shaik, G. Zhang, J. Zhe. “Rapid Surface Charge Mapping Based on a Liquid Crystal Microchip”, Biosensors, 2024, 12,199, DOI: 10.3390/bios14040199

• R. Xu, L. Ouyang, R. Shaik,  H. Chen, G. Zhang, J. Zhe. “Rapid Detection of Microparticles Using a Microfluidic Resistive Pulse Sensor Based on Bipolar Pulse-Width Multiplexing”, Biosensors, 2023, 13, 721. R. Xu, L. Ouyang, H. Chen, G. Zhang, J. Zhe. “Recent Advances in Biomolecular Detection Based on Aptamers and Nanoparticles”, Biosensors, 2023, 13, 474., DOI: 10.3390/bios13070721

• R. Shaik, J. Xu, Y. Wang, Y. Hong*, G. Zhang*, “Fibrin-Enriched Cardiac Extracellular Matrix Hydrogel Promotes In Vitro Angiogenesis”, ACS Biomaterials Science & Engineering, 2023, 9, 877-888., DOI:10.1021/acsbiomaterials.2c01148

• L. Ouyang, R. Shaik,  R. Xu,  G. Zhang, J. Zhe. “Cell Surface Charge Mapping Using a Microelectrode Array on ITO Substrate” Cells, 2023, 12, 518., DOI: https://doi.org/10.3390/cells12040518

• R. Xu, L.Ouyang, R. Shaik, G. Zhang, J. Zhe “Multiplexed Resistive Pulse Sensor Based on Geometry Modulation for High-throughput Microparticle Counting” Sensors and Actuator Reports, 2023, 5, 100140., DOI:10.3390/cells12040518

• R. Xu, L Abune, B. Davis, L. Ouyang, G. Zhang, Y. Wang, J. Zhe, “Ultrasensitive Detection of Small Biomolecules Using Aptamer-based Molecular Recognition and Nanoparticle Counting” Biosensor and Bioelectronics, 2022, 203,114023., DOI: 10.1016/j.bios.2022.114023

• L. Ouyang, R. Shaik, R. Xu, G. Zhang*; J. Zhe*, “Mapping Surface Charge Distribution of Single-Cell via Charged Nanoparticle” Cells, 2021, 10, 1519.  (* corresponding author), DOI: 10.3390/cells10061519

• E. Mulvany, S. McMahan, J. Xu, N. Yazdani, R. Willits, J. Liao, G. Zhang*, Y. Hong*, “In vitro comparison of harvesting site effects on cardiac extracellular matrix hydrogels” Journal of Biomedical Materials Research Part A, 2021,109(10),1922-1930., DOI: 10.1002/jbm.a.37184

• B. L. Brazile, J. R. Butler, S. S. Patnaik, A. Claude, R. Prabhu, L. N. Williams, K. L. Perez, K.T. Nguyen, G. Zhang, P. Bajona, M. Peltz, Y. Yang, Y. Hong, J. Liao, “Biomechanical properties of acellular scar ECM during the acute to chronic stages of myocardial infarction” Journal of the Mechanical Behavior of Biomedical Materials, 2021, 116; 104342., DOI: 10.1016/j.jmbbm.2021.104342

• N Rashidi, A.D. Pant, S.D. Salinas, M. Shah, V.S. Thomas, G. Zhang, S. Dorairaj, R. Amini, “Iris stromal cell nuclei deform to more elongated shapes during pharmacologically-induced miosis and mydriasis” Experimental Eye Research, 2021; 202:108373., DOI: 10.1016/j.exer.2020.108373

• P. KC, M. Shah, R. Shaik, Y. Hong, G. Zhang, “Preseeding of Mesenchymal Stem Cells Increases Integration of an iPSC-Derived CM Sheet into a Cardiac Matrix” ACS Biomaterials Science & Engineering, 2020, 6 (12), 6808-6818., DOI: 10.1021/acsbiomaterials.0c00788

• N. Zhao, J. Coyne, L. Abune, P. Shi, X.L. Lian, G. Zhang, Y. Wang, “Exogenous Signaling Molecules Released from Aptamer-Functionalized Hydrogels Promote the Survival of Mesenchymal Stem Cell Spheroids” ACS Applied Materials and Interfaces, 2020, 12(22), 24599-24610., DOI:10.1021/acsami.0c05681

• L. Ni, R. Shaik, R. Xu, G. Zhang*, J. Zhe*, “A Microfluidic Sensor for Continuous, in Situ Surface Charge Measurement of Single Cells” ACS Sensors, 2020, 5(2), 527-534., DOI:10.1021/acssensors.9b02411

• D. Zhang, F. Yang, J. He, L. Xu, T. Wang, Z Q Feng, Y. Chang, X. Gong, G. Zhang, J. Zheng, “Multiple Physical Bonds to Realize Highly Tough and Self-Adhesive Double-Network Hydrogels” ACS Applied Polymer Materials, 2020 2 (3), 1031-1042., DOI: https://doi.org/10.1021/acsapm.9b00889

• L. Ni, P. Kc, G. Zhang*, J. Zhe*, “Enabling single cell electrical stimulation and response recording via a microfluidic platform” Biomicrofluidics, 2019,13(6), 064126., DOI:10.1063/1.5128884

• M. Shah, P. KC, G. Zhang, “In Vivo Assessment of Decellularized Porcine Myocardial Slice as an Acellular Cardiac Patch” ACS Applied Materials and Interfaces, 2019, 11(27), 23893-23900., DOI:10.1021/acsami.9b06453

• L. Ni, P. KC, E. Mulvany, G. Zhang*, J. Zhe*, “A microfluidic device for noninvasive cell electrical stimulation and extracellular field potential analysis” Biomed Microdevices, 2019;21(1): 20., DOI:10.1007/s10544-019-0364-2

• N. Zhao, A. Suzuki, X. Zhang, P. Shi, L. Abune, J. Coyne, H. Jia, N. Xiong, G. Zhang, Y. Wang, “Dual Aptamer-Functionalized in Situ Injectable Fibrin Hydrogel for Promotion of Angiogenesis via Codelivery of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor-BB” ACS Applied Materials and Interfaces, 2019;11(20):18123-18132., DOI:10.1021/acsami.9b02462

• P. KC, Y. Hong, G. Zhang, “Cardiac tissue-derived extracellular matrix scaffolds for myocardial repair: advantages and challenges” Regenerative Biomaterials, 2019; 6(4), 185–199., DOI:10.1093/rb/rbz017

• M. Shah, P. KC, K Copeland, J. Liao, G. Zhang, “A Thin Layer of Decellularized Porcine Myocardium for Cell Delivery” Scientific Reports, 2018 (8), Article number: 16206., DOI:10.1038/s41598-018-33946-2

• F. Liu, P. KC, Ni, L., G. Zhang*, J. Zhe*, “Microfluidic Competitive Immuno-aggregation Assay for High Sensitivity Cell Secretome Detection” Organogenesis, 2018; 8:1-15., DOI:10.1080/15476278.2018.1461306

• P. KC, F Liu, J. Zhe, G. Zhang, “Development and Comparison of Two Immuno-disaggregation Based Bioassays for Cell Secretome Analysis” Theranostics, 2018, 8(2), 328-340., DOI:10.7150/thno.21917

• P. KC, M. Shah, J. Liao, G. Zhang, “Prevascularization of Decellularized Porcine Myocardium Slice for Cardiac Tissue Engineering” ACS Applied Materials and Interfaces, 2017; 9 (3), 2196-2204., DOI: https://doi.org/10.1021/acsami.6b15291

• F. Liu, P. KC, G. Zhang*, J Zhe*, “In Situ Single Cell Detection Via Microfluidic Magnetic Bead Assay” PLOS One, 2017; 12: e0172697. , DOI: 10.1371/journal.pone.0172697

• F. Liu, P. KC, G. Zhang*, J. Zhe*, “Microfluidic Magnetic Bead Assay for Cell Detection” Analytical Chemistry, 2016, 88, 711-717., DOI:10.1021/acs.analchem.5b02716

• M. Shah, R. George, M. Chapman, G. Zhang, “Current Challenges in Dedifferentiated Fat Cells Research” Organogenesis, 2016; 12(3); 119-127., DOI:10.1080/15476278.2016.1197461

• B. Wang, S. Patnaik, B. Brazil, J. Butler, A Claude, G. Zhang, J. Guan, Y. Hong, J. Liao, “Establish Early Functional Perfusion and Structure in Tissue Engineered Cardiac Constructs” Critical Reviews in Biomedical Engineering, 2015, 43(5-6), 455-471., DOI: 10.1615/CritRevBiomedEng.2016016066

• M.E. Jeffords, J. Wu, M. Shah, Y. Hong, G. Zhang, “Tailoring Material Properties of Cardiac Matrix Hydrogels to Induce Endothelial Differentiation of Human Mesenchymal Stem Cells” ACS Applied Materials & Interfaces, 2015, 7 (20), 11053–11061., DOI:10.1021/acsami.5b03195

• N. Patel, G. Zhang, “Stacked stem cell sheets enhance cell-matrix interactions” Organogenesis, 2014,10 (2), 1-7., DOI:10.4161/org.28990

• B. Liu, M. Shah, G. Zhang, Q. Liu, Y. Pang, “Biocompatible Flavone-based Flurogenic Probes for Quick Wash-Free Mitochondrial Imaging in Living Cells” ACS Applied Materials & Interfaces, 2014, 10, 6(23), 21638-44., DOI: 10.1021/am506698f

• J. Wang, Y Li, N. Patel, G. Zhang, D. Zhou, Y. Pang, “A single molecular probe for multi-analyte (Cr³⁺, Al³⁺ and Fe³⁺) detection in aqueous medium and its biological application” Chemical Communications, 2014, 50, 12258-12261., DOI:10.1039/c4cc04731a

• B. Liu, Q. Liu, M. Shah, J. Wang, G. Zhang, Y. Pang, “Fluorescence monitor of hydrazine in vivo by selective deprotection of flavonoid” Sensors and Actuators B, 2014, 202, 194-200., DOI: 10.1016/j.snb.2014.05.010 

• B. Liu, J. Wang, G. Zhang, R. Bai, Y. Pang, “Flavone-based ESIPT ratiometric chemodosimeter for detection of cysteine in living cells” ACS Applied Materials and Interfaces, 2014, 26, 6(6), 4402-7., DOI:10.1021/am500102s

• Q. Wang, G. Liang, M. Zhang, J. Zhao, K. Patel, X. Yu, C. Zhao, B. Ding, G. Zhang, F. Zhou, J. Zheng, “De novo design of self-assembled hexapeptides as beta-amyloid (Abeta) peptide inhibitors” ACS Chemical Neuroscience, 2014, 5, 972-981., DOI: https://doi.org/10.1021/cn500165s

• Y. Xu, S. Patnaik, X. Guo, Z. Li, W. Lo, Z. Liu, G. Zhang, J. Liao, P. Anderson, J. Guan, “Cardiac Differentiation of Cardiosphere-Derived Cells in Scaffolds Mimicking Morphology of the Cardiac Extracellular Matrix” Acta Biomaterialia, 2014, 10(8), 3449-62., DOI: https://doi.org/10.1016/j.actbio.2014.04.018

• R. Hu, M. Zhang, K. Patel, Q. Wang, Y. Chang, X. Gong, G. Zhang, J. Zheng, “Cross-sequence interactions between human and rat islet amyloid polypeptides” Langmuir, 2014, 30, 5193-5201., DOI: https://doi.org/10.1021/la500632d

• C. Zhao, K. Patel, L.M. Aichinger, Z. Liu, R. Hu, H. Chen, X. Li, L. Li, G. Zhang, Y. Chang, J. Zheng, “Antifouling and biodegradable poly(N-hydroxyethyl acrylamide) (polyHEAA)-based nanogels” RSC Advances, 2013, 3,19991-20000. DOI: 10.1039/C3RA42323A

• N.G. Patel, G. Zhang, “Responsive Systems for Cell Sheet Detachment” Organogenesis, 2013, 9 (2), 93-100., DOI: 10.4161/org.25149

• Q. Wang, X. Yu, K. Patel, R. Hu, S. Chuang, G. Zhang*, J. Zheng*, “Tanshinones inhibit amyloid aggregation by amyloid-β peptide, disaggregate amyloid fibrils, and protect cultured cells” ACS Chemical Neuroscience, 2013, 4, 1004-1015, DOI: https://doi.org/10.1021/cn400051e

• C. Zhao, Q. Chen, K.Patel, L. Li, X Li,Q. Wang, G. Zhang, J. Zheng “Synthesis and characterization of pH-sensitive poly(N-2-hydroxyethyl acrylamide)–acrylic acid (poly(HEAA/AA)) nanogels with antifouling protection for controlled release” Soft Matter, 2012, 8, 3848-3857. , DOI:10.1039/C2SM25861G

• N. Patel, J Cacicchia, G. Zhang*,B.Z. Newby*,“Rapid Cell Detachment using spin-Coated pNIPAAm Films Retained on Surfaces by an Aminopropyltriethoxysilane Network” Acta Biomaterialia, 2012, 8, 2559-2567. DOI: 10.1016/j.actbio.2012.03.031

Other Institutions

• S. Natesan, G. Zhang, D.G. Baer, T.J. Walters, R.J. Christy,L.J. Suggs, “A Bilayer Construct Controls Adipose Derived Stem Cell Differentiation into Endothelial Cells and Pericytes without Growth Factor Stimulation” Tissue Engineering Part A, 2011, 17(7-8), 941-53.DOI: 10.1089/ten.TEA.2010.0294

• G. Zhang, C.T. Drinnan, L.R. Geuss, L.J. Suggs, “Vascular differentiation of bone marrow stem cells is directed by a tunable 3D matrix” Acta Biomaterialia, 2010, 6(9), 3395-3403. DOI: 10.1016/j.actbio.2010.03.019

• C.T. Drinnan, G. Zhang, M.A. Alexander, A.S. Pulido, L.J. Suggs, “Multimodal Release of Transforming Growth Factor-a1 and the BB Isoform of Platelet Derived Growth Factor from PEGylated Fibrin Gels” Journal of Controlled Release, 2010, 147(2), 180-185. DOI: 10.1016/j.jconrel.2010.03.026

• G. Zhang, Q. Hu, E. Braunlin, L.J. Suggs, J. Zhang, “Enhancing Efficacy of Cell Transplantation in Hearts with Post-infarction LV Remodeling by an Injectable Biomatrix” Tissue Engineering Part A, 2008, 14(6): 1025-1036. DOI: https://doi.org/10.1089/ten.tea.2007.02

• G. Zhang, L.J. Suggs, “Matrices and Scaffolds for Drug Delivery in Vascular Tissue Engineering” Advanced Drug Delivery Reviews, 2007, 59(4-5), 360-73. DOI: https://doi.org/10.1016/j.addr.2007.03.018

• L. Zeng, Q. Hu, X. Wang, A. Mansoor, J. Lee, J. Feygin, G. Zhang, P. Suntharalingam, S. Boozer, A. Mhashilkar, C.J. Panetta, C. Swingen, R. Deans, A.H. From, R.J. Bache, C.M. Verfaillie, J. Zhang, “Bioenergetic and functional consequences of bone marrow-derived multipotent progenitor cell transplantation in hearts with postinfarction left ventricular remodeling” Circulation, 2007, 115(14), 1866-75. DOI:10.1161/CIRCULATIONAHA.106.659730

• G. Zhang, Y. Nakamura, X. Wang, Q. Hu, L.J. Suggs, J. Zhang, “Controlled Release of Stromal Cell Derived Factor-1α in situ Increases Stem Cell Homing to the Infarcted Heart.” Tissue Engineering, 2007,13(8), 2063-71. DOI:10.1089/ten.2006.0013

• Q. Hu, X. Wang, J. Lee, A. Mansoor, J. Liu, L. Zeng, C. Swingen, G. Zhang, J. Feygin, K Ochiai, K. Bransford, R. Bache, J. Zhang, “Profound bioenergetic abnormalities in peri-infarct myocardial regions” American Journal of Physiology-Heart and Circulatory Physiology, 2006, 291, H648-57. DOI: https://doi.org/10.1152/ajpheart.01387.2005

• X. Wang, Q. Hu, Y. Nakamura, J. Lee, G. Zhang, A.H. Form, J. Zhang, “The Role of Sca-1+/CD31- Cardiac Progenitor Cell Population in Postinfarction LV Remodeling” Stem Cells, 2006, 24, 1779-1788. DOI: https://doi.org/10.1634/stemcells.2005-0386

• G. Zhang, Z. Wang, X. Wang, J. Zhang, L.J. Suggs “A PEGylated Fibrin Patch for Mesenchymal Stem Cell Delivery” Tissue Engineering, 2006, 12(1): 9-19. DOI: https://doi.org/10.1089/ten.2006.12.9