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Innovate4Health Innovation

Innovate4Health: Augmented Reality Technology Helps Bring Surgical Expertise to Conflict Zones and the Developing World

This post is one of a series in the #Innovate4Health policy research initiative.

Innovate4HealthBy Gleb Savich

The majority of people in the world do not have access to safe and affordable surgical care. More than 2 billion people cannot receive surgical care simply because there are no surgical facilities where they live. Up to 3 billion more people do not have access to surgical care that is safe, timely, and affordable. The availability of surgical care is extremely uneven around the world. While 95% of the population of South Asia and several regions of Africa lack access to surgical care, less than 5% of the population of the high income areas of North America and Western Europe lack such access.

doctors in surgeryThe problem of access to surgical care may be particularly acute in conflict zones, where the need is often the greatest. Getting much-needed surgical expertise in war-ravaged countries is already a nearly impossible task. To make matters worse, in such countries as Syria, Yemen, and Sudan, targeting healthcare workers and facilities for destruction has become a warfare strategy.

Talal Ali Ahmad is a Boston-based Lebanese entrepreneur who built his career in mobile phone development. While on a mission to El Salvador as a volunteer for the Global Smile Foundation, he observed firsthand the obstacles faced by doctors providing healthcare in remote regions. Leveraging his background in mobile phone technology, Ahmad began developing tools that allow surgeons to remotely assist their colleagues with surgical procedures.

To further develop and implement the technology, Ahmad teamed up with Nadine Hachach-Haram, a London-based Lebanese surgeon. Together, they founded Proximie, bringing together a team of clinicians, engineers, and designers. In 2016, Ahmad obtained a patent on his invention and secured the backing of a Lebanese venture capital firm, Cedar Mundi Holdings.

Diagram. Top center box: Electronic Health Records 180. Bottom center box: Server 120. A two-way arrow connects the boxes. Left box: Local Site 110. A doctor (labeled 14) stands by a bed (labeled 160). Right box: Remote Site 130. A doctor (labeled 150) stands by a computer (labeled 170). Two-way arrows connect the bottom center box with both the left and right boxes.The augmented reality technology that Ahmad and his team developed, also called Proximie, is simple. It uses any pair of computers, tablets, or smartphones with cameras. One unit is located at the site of surgery, and the other is at a remote location. A surgeon at the remote location can observe the surgical field as 2D or 3D images or a real-time video feed. Using a touchscreen, the remote surgeon can make markings that are overlaid on the images of the surgical field and transmitted to the surgical site. For example, the remote surgeon can mark where to make an incision. The remote surgeon and the local team can communicate with each other by audio or text.

A more sophisticated version of Proximie utilizes a dataglove that senses the position and movements of the wearer’s hand. The hand movements of the remote surgeon wearing such a glove are overlaid on the images of the surgical field and transmitted to the site of surgery, guiding the local team on how to perform a procedure.

Proximie utilizes existing technology and can be implemented on any suitable device or platform. Its simple interface allows doctors to use the platform with just a few days of training. This simplicity and accessibility is critical. Dr. Hachach-Haram explains: “What attracts us to this is that the challenges facing public healthcare are hugely complex, yet the solutions offered by technology are beautifully simple. This idea of bringing forms of surgery to places where they haven’t been available before with nothing more than an internet connection and mobile devices seems very powerful to us.”

Fig 5. Diagram. Medical Instruction Interface in rectangle. Participants (labeled 510) in upper left box: Drs. John Smith, Mary Jones, and Paul Davis. Live video in lower left box, labeled 520; image of baby’s face, labeled 521. Boxes under image labeled 1, 2, 3, +, and an arrow, all labeled together as 522. Center box: Work area, labeled 530. Large image of baby’s face, labeled 531. Selection on nose, marked 532. Ruler for scale, marked 534. Boxes underneath marked 1 through 5, labeled 533 together. Long right box, Snapshots, labeled 540. Three images on top of each other of baby’s face. Top labeled 541, with arrow pointed at baby’s left nostril and labeled 542. Middle labeled 541, with arrow pointed at baby’s right nostril and labeled 542. Bottom labeled 541, with selection of baby’s mouth labeled 542. Boxes underneath marked 1 through 3 and labeled together as 543.Proximie conducted its initial trials in 2015 in collaboration with the Global Smile Foundation. Surgeons in the U.S. guided teams in Peru and El Salvador in repairing cleft palates of local children. The following year, surgeons in Gaza, Syria, and Iraq performed wound surgeries assisted by their colleagues in Lebanon using Proximie.

Dr. Abu-Sitta, a plastic surgeon, used Proximie to lead surgeries in the Gaza strip from his home base in Beirut, hundreds of miles away. In one such surgery, he showed the local surgeons in Gaza how to repair a blast injury. In another, he showed them how to operate on a congenital hand anomaly. Previously, Dr. Abu-Sitta tried helping overseas surgeons by sending them audio recordings, photos, and X-rays. But Proximie is far more interactive. Dr. Abu-Sitta notes: “We wanted to push the idea that with only the minimum hardware, and minimum infrastructure you can still pull it off. With just two tablets, iPad to iPad, we’re able to perform this surgery.”

One of the surgeons that conducted the surgery in Gaza described his experience: “It is like the consultant is with you in the same room, giving you an opinion so that the surgery can be perfect.”

In addition to helping surgeons in remote areas and conflict zones to benefit from the expertise and real-time guidance of experts located elsewhere in the world, Proximie can be a valuable training tool. Proximie has partnered with the Royal Free Hospital and University College London in the U.K. and Yale Medical School in the U.S. to provide support for medical students. “Surgeries are being streamed from the Royal Free Hospital theaters and the students can log on and interact directly with the operating surgeon. Students can also capture and store photos and videos on Proximie’s cloud-based server for future learning,” explains Dr. Hachach-Haram.

Driven by their belief that everyone should benefit from the same high quality of healthcare and training opportunities, no matter where they live, the Proximie team continues to develop their technology to increase access to surgical care and training around the world.

#Innovate4Health is a joint research project by the Center for the Protection of Intellectual Property (CPIP) and the Information Technology & Innovation Foundation (ITIF). This project highlights how intellectual property-driven innovation can address global health challenges. If you have questions, comments, or a suggestion for a story we should highlight, we’d love to hear from you. Please contact Devlin Hartline at jhartli2@gmu.edu.

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Innovate4Health Innovation

Innovate4Health: Indian Startup Develops Nanomaterial Filter to Help Solve Global Drinking Water Crisis

This post is one of a series in the #Innovate4Health policy research initiative.

Innovate4HealthBy Gleb Savich

Access to clean water remains a critical issue on a global scale. According to the latest statistics by the World Health Organization (WHO), 844 million people lack a basic drinking water service and at least 2 billion people use contaminated water that can transmit cholera, dysentery, typhoid, polio, and other diseases. Contaminated drinking water causes more than 500,000 deaths each year. And in low- and middle-income countries, more than one-third of the health care facilities lack even soap and water for handwashing.

many hands catching water under a faucetThis drinking water crisis disproportionately affects the poor in the developing world. However, problems with access to safe drinking water may arise in any part of the world due to man-made or natural disasters—including in the United States. One recent example is the public health crisis that erupted in Flint, Michigan, where drinking water became contaminated with lead when the city switched to a different water source.

Natural disasters may disrupt the water supply in areas that normally have access to safe drinking water. As of October 2017, over a month after Hurricane Maria devastated the island of Puerto Rico, many of its residents still did not have access to clean water, precipitating an outbreak of leptospirosis, a rare bacterial disease.

Climate change, population growth, and urbanization pose further challenges to water supply systems. According to the World Health Organization, by 2025, half of the world’s population will be living in water-stressed areas. These varied challenges to one of humanity’s most fundamental problems require flexible and creative solutions. 

Dr. Thalappil Pradeep is a professor in the Department of Chemistry at the Indian Institute of Technology (IIT) Madras. His decades of research focusing on nanomaterials has led to several discoveries that have already begun to help solve the global problem of access to clean drinking water.

The first breakthrough came in 2004 when Dr. Pradeep’s team developed nanoparticles that can break down certain pesticides dissolved in water. Many of these chemicals are not removable by standard water filters and have been shown to pose environmental and health risks. Although the use of some of these pesticides is banned, the compounds persist in the environment decades later. The problem is particularly relevant in India, one of the world’s largest pesticide producers, where pesticide water contamination is a serious problem in certain areas.

enlarged image of a moleculeThe pesticide removal technology developed by Dr. Pradeep and his colleagues works by utilizing the ability of gold and silver nanoparticles to bind pesticides from flowing water through adsorption. Dr. Pradeep and his coinventor obtained both Indian and U.S. patents on their technology and licensed it to Eureka Forbes, an Indian manufacturer of vacuum cleaners and water purifiers.

The technology is estimated to have reached 7.5 million people and is the first nanomaterials-based water filter to be commercialized. To further develop nanomaterials-based water filtration technologies, Dr. Pradeep and his team founded a startup, InnoNano Research, in 2004.

Their next breakthrough came in 2012, when the team developed a novel nanomaterial capable of being adapted for the removal of multiple types of water contaminants. The new filter, dubbed AMRIT for Arsenic and Metal Removal by Indian Technology, can remove microbial contamination as well as arsenic, iron, and other heavy metals from drinking water.

The antimicrobial properties of silver ions were well known, but their large-scale implementation for water filtration had been hampered by technological obstacles, such as lack of suitable substrates in which to embed the ions. The novel nanoparticle material developed by Dr. Pradeep and his team solves these issues.

Silver nanoparticles are embedded in this material to remove microbes, while the incorporation of other compounds allows for the removal of other contaminants. For example, the incorporation of iron achieves the removal of both iron and arsenic. Thus, this technology allows for manufacturing of multistage filtration systems suitable for particular needs.

Discussing this filtration system, Dr. Pradeep explains: “If this will be useful for water, it has to be very cheap, have a low carbon footprint, require no electricity, and should not contaminate water sources in the process.” And his team’s technology meets these challenges. According to : Dr. Pradeep, manufacturing requires no heating or electricity and uses materials with a low carbon footprint.

Removal of arsenic from drinking water is of particular interest in India, where ground waters used for drinking and irrigation are often contaminated with dangerous levels of arsenic. To begin addressing this problem, by the summer of 2016, AMRIT filters were installed in 750 locations in several Indian provinces, providing clean water to nearly half a million people.

In 2016, InnoNano Research succeeded in securing one of the largest investments for an Indian tech startup when it obtained $18 million from Nanoholdings LLC, a U.S. venture capital firm specializing in investing into material science-based energy and water startups. This investment is particularly significant in light of the difficulties that Indian startups often face when it comes to scaling up their technologies.

Dr. Pradeep explains: “We have no efficient mechanisms for partnering, scaling and incubating – those are the lacunae in our system.” While universities provide startups with access to labs and research grants, more funding is needed to achieve the scale necessary for further product development.

Leveraging intellectual property enables startups to raise funds necessary to bring their innovations to those who need them. With the help of Nanoholdings LLC, Dr. Pradeep hopes to expand the company’s operations into Africa, Southeast Asia, and Latin America, and to continue developing the technology to filter out other dangerous contaminants found in drinking water.

#Innovate4Health is a joint research project by the Center for the Protection of Intellectual Property (CPIP) and the Information Technology & Innovation Foundation (ITIF). This project highlights how intellectual property-driven innovation can address global health challenges. If you have questions, comments, or a suggestion for a story we should highlight, we’d love to hear from you. Please contact Devlin Hartline at jhartli2@gmu.edu.

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Innovate4Health

Innovate4Health: Embrace Infant Warmers Help Save Lives of Preterm Babies in Developing Countries

This post is one of a series in the #Innovate4Health policy research initiative.

Innovate4HealthBy Gleb Savich

Preterm birth is the leading cause of death for children under five years old. An estimated 15 million babies are born before 37 weeks gestation each year, and nearly 1 million children under five die due to complications associated with such births. Nearly three quarters of them could be saved with current interventions. The disparity in survival rates of preterm babies based on a country’s wealth is startling. In high-income countries, almost all of the babies born after 32 weeks survive, but in low-income countries, only half survive.

Hypothermia is a significant factor contributing to the death of preterm babies. Preterm newborns are particularly vulnerable to hypothermia because they cannot generate enough heat to warm themselves on their own. They also have less stored fat to insulate themselves against heat loss. Infant incubators are commonly used in neonatal care units to help preterm infants maintain safe body temperature. Such equipment costs thousands of dollars and requires a stable source of electricity to operate.

Healthcare interventions in the developing world often prove ineffective. Expensive equipment donated to hospitals in the developing countries is often useless because a stable electricity supply and replacement parts are unavailable. Despite long-term efforts of well-intentioned people, innovative solutions have been needed to meet these local challenges rather than more donations of existing technology.

diagram of an infant in an infant warmerSpecifically, there has been a need to design infant incubators that address the unique challenges of the developing world. Embrace infant warmers, which were developed through a project class at Stanford University called Design for Extreme Affordability, were designed to meet these challenges. Embrace infant warmers have won several awards, including the Economist Innovation Award and TED Fellows award.

Projects start with developing-world challenges in mind, and students create innovative solutions that address problems with using existing technology. An integral part of the course are need-finding trips, during which the students learn about the needs of the target community while on location. This enables the students to formulate an appropriate design process while also establishing deep connections with the members of the community.

The challenge leading to Embrace was to create a cheap infant incubator. They started by visiting hospitals in Nepal, and they quickly realized that most births occur in villages far away from hospitals with stable sources of electricity. Donated infant incubators were available, but they were left in storage because the birth facility lacked the infrastructure to use the machines.

The team designed a portable device capable of maintaining the infant at approximately body temperature without having to be continuously connected to an electricity source. It is able to do so by utilizing specialized temperature-regulating materials that keep a near-constant temperature despite gaining or losing heat energy.

diagram of an open infant warmerThese materials are called “phase change materials” because they melt or solidify (in other words, they change phases) near body temperature. People normally think about the transfer of heat energy as making one thing warmer or another thing colder, but this is not true during a phase change. For example, during solidification, the material releases heat energy, which can be used to keep the infant warm, but it maintains its own temperature because the heat comes from the process of solidification rather than a loss of temperature.

Embrace infant warmers look like a swaddle or a tiny sleeping bag that cradles an infant. A temperature-regulating element is placed between the inner and outer fabric layers of the infant warmer. This element contains the phase change material, chosen so that it melts or solidifies around normal human body temperature.

The temperature-regulating element can be heated or cooled to the desired temperature utilizing a recharging unit plugged into an electrical outlet or by placing the element into warm or cool water. Thus, no electricity is required to use the device. But even intermittent power sources can be beneficial because the unit can be charged when it is not in use. Once at the desired temperature, the temperature-changing element is inserted between the fabric layers of the infant warmer. One current version of the infant warmer maintains the desired temperature for at least 4 hours.

diagram of a baby in an unrolled baby warmerTo further advance their invention, the team founded the Embrace Innovations company and have begun developing a strong patent portfolio. Secure and effective patent rights allow the enterprise to grow and adapt in furtherance of their mission. This includes adopting strategies such as providing products through for-profit and nonprofit mechanisms and contracting with third-party manufacturers to produce the devices. Income derived from the initial innovations can then be used for additional projects that will further benefit the developing world.

Today, Embrace infant warmers are manufactured by Phoenix Medical Systems in India and are available for a small fraction of the cost of standard incubators. The nonprofit arm of the company, Embrace Global, is a part of Thrive Networks, an international NGO that utilizes evidence-based innovations to improve the lives of underserved populations in Southeast Asia.

The Embrace team has also gone on to develop other products: sleeping bags and swaddles for infants under the brand, Little Lotus. Like Embrace infant warmers, these products utilize phase change materials to ensure optimal sleeping temperature for babies. A portion of proceeds from every purchase of a Little Lotus product goes to providing access to Embrace infant warmers, showing how parallel projects can be used to benefit vulnerable populations in the developing world.

With the help of Embrace Global and its partners, Embrace infant warmers have been used to care for over 200,000 low birth weight and premature infants across 20 countries in the developing world. This is the result of both the important innovation and the forward-thinking development that can only occur when inventors have control over the ideas they create.

#Innovate4Health is a joint research project by the Center for the Protection of Intellectual Property (CPIP) and the Information Technology & Innovation Foundation (ITIF). This project highlights how intellectual property-driven innovation can address global health challenges. If you have questions, comments, or a suggestion for a story we should highlight, we’d love to hear from you. Please contact Devlin Hartline at jhartli2@gmu.edu.