Richard L. Londraville, Ph. D.

Professor of Biology, University of Akron


Publications-Dr. Richard Londraville

Londraville Richard L., Tuttle Matthew, Liu Qin, Andronowski Janna M. 2022. Endospanin is a candidate for regulating leptin sensitivity. Front. Physiol. 12:2307 

Buo C, Taylor E , Dayal P , Bartles J, Christman K & Londraville RL. 2020. Spatial mapping influences navigation in Entomacrodus striatus.  Mar Fr Water Behav Physiol.

Cohn E, Cole P, Haymaker A, Garner AM, Londraville RL. 2020. Response to underwater laser pointer in the Orange-finned Anemonefish Amphiprion chrysopterus and three-spot damselfish Dascyllus trimaculatus. J Fish Biol.  96:274-277.

Tuttle M, Dalman MR, Liu Q, Londraville RL. 2019. Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio) PeerJ 7:e6848

R.L. Londraville, Prokop J. W., Duff R. J., Liu Q., Tuttle M. 2017. On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin. Front. Endocrin.  8:58.

H. C. Ball, R. L. Londraville, J. W. Prokop, J. C. George, R. S. Suydam, C. Vinyard, J. G. M. Thewissen, R. J. Duff 2017. Beyond thermoregulation:metabolic function of cetacean blubber in migrating bowhead and beluga whales. J. Comp. Physiol. B.  Jan;187(1):235-252. doi: 10.1007/s00360-016-1029-6. Epub 2016 Aug 29.doi:10.1007/s00360-016-1029-6 [Epub ahead of print]. Aug 29.

Bhattarai S1, Sochacka-Marlowe A1, Crutchfield G1, Khan R1, Londraville R1, Liu Q2. 2016. Krüpple-like factors 7 and 6a mRNA expression in adult zebrafish central nervous systemGene Expr Patterns. 2016 May;21(1):41-53. doi: 10.1016/j.gep.2016.06.004. Epub 2016 Jun 27.

Ball HC1, Stavarz MOldaker JUsip SLondraville RLGeorge JCThewissen JGDuff RJ. 2015. Seasonal and ontogenetic variation in subcutaneous adipose of the bowhead whale (Balaena mysticetus). Anat Rec (Hoboken).  298(8) 1416-1423.

Dores RM1Londraville RL2Prokop J2Davis P2Dewey N2Lesinski N2. 2014. Molecular evolution of GPCRs: Melanocortin/melanocortin receptors. J Mol Endocrinol. 2014 Jun;52(3):T29-42. doi: 10.1530/JME-14-0050.

Prokop JW1Schmidt C2Gasper D2Duff RJ2Milsted A2Ohkubo T3Ball HC2Shawkey MD2Mays HL Jr4Cogburn LA5Londraville RL2. 2014. Discovery of the elusive leptin in birds: identification of several ‘missing links’ in the evolution of leptin and its receptor. PLoS One. 2014 Mar 24;9(3):e92751. doi: 10.1371/journal.pone.0092751. eCollection 2014.

Londraville RL1Macotela Y2Duff RJ3Easterling MR4Liu Q3Crespi EJ4. 2014. Comparative endocrinology of leptin: assessing function in a phylogenetic contextGen Comp Endocrinol. 2014 Jul 1;203:146-57. doi: 10.1016/j.ygcen.2014.02.002. Epub 2014 Feb 11

Dalman MR, Liu Q, King MD, Bagatto B and Londraville RL (2013) Leptin expression affects metabolic rate in zebrafish embryos (D. rerio)Front. Physiol4:160. doi: 10.3389/fphys.2013.00160

Ball, H.C., Holmes, R.K., Londraville, R.L. Thewissen, J.G.M., Duff, R.J. 2013. Leptin in Whales: Validation and measurement of mRNA expression by absolute quantitative real-time PCR. PLOS One. 8(1) e542771-11.

Prokop, J.W., R.J. Duff, H.C. Ball, D.L. Copeland, R.L. Londraville. 2012. Leptin and leptin receptor: Analysis of a structure to function relationship in interaction and evolution from humans to fish. Peptides 38:326-336

Chen, Y., Londraville, R.L., Brickner, S., El-Shaar, L., Fankhauser, K., Dearth, C., Fulton, L. Sochacka, A., Bhattarai, S., Marrs, J.A., Liu, Q., 2012. Protocadherin-17 function in zebrafish retinal development. Dev. Neurobiol.  Aug 28 doi: 10.1002/dneu.22053

Q. Liu, M. Dalman, Y. Chen, M. Akhter, S. Brahmandam, Y. Patel, J. Lowe, M. Thakkar, A. Gregory, D. Phelps, C. Riley, and R.L. Londraville. 2012. Knockdown of leptin A expression dramatically alters zebrafish development. Gen. Comp. Endocrinol.  178 (3) 562-572.

D. L. Copeland, R.J. Duff, Q. Liu, J. Prokop, and R.L. Londraville. 2011. Leptin in Teleost Fishes: An Argument for Comparative Study. Front. Aquat. Physiol. June 2011 Vol 2 Article 26

R.L. Londraville and Niewiarowski, P.H. 2010. Leptin signaling systems in reptiles and amphibians. In: Leptin in Non-Mammalian Vertebrates. Ed. by M. Paolucci. Published by Research Signpost, Kerala, India.

Q. Liu, Chen, Y. Copeland, D. Ball H., Duff, R.J., Rockich, B., Londraville, RL. 2009. Expression of leptin receptor gene in developing and adult zebrafishGen. Comp. Endocrinol. Available online 11/24/09. doi:10.1016/j.ygcen.2009.11.015

Heflin, B., Young, L., and R. Londraville. 2009.  Short-term cycling of skin colouration in the blackspotted rockskipper Entomacrodus striatus.  J. Fish Biol.  74: 1635-1641. Published Online: Apr 27 2009DOI: 10.1111/j.1095-8649.2009.02200.

Jury, D.R., Kaveti, S., Duan, Z-H, Willard, B., Kinter, M. and R. Londraville. 2008. Effects of calorie restriction on  the zebrafish proteome. Comp. Biochem. Physiol. D. 3:275-282.

Liu, Q., R.L. Londraville, J.A. Marrs, A.L. Wilson, T. Mbimba, T. Murakami, F. Kubota, W. Zheng, and D.G.  Fatkins. 2008. Cadherin-6 function in zebrafish retinal development. Develop. Neurobiol. Published  online May 27 2008.

Liu, B., R.J. Duff, R. L. Londraville, J.A. Marrs and Q. Liu. 2007.  Cloning and expression analysis of cadherin 7 I  n the central nervous system of the embryonic zebrafish.  Gene Express. Patterns 7(1-2) 15-22 .

Spanovich, S., Niewiarowski, P.H., and R. L. Londraville. 2006. Seasonal effects on circulating leptin in the lizard Sceloporus undulatus from two populations.  Comp. Biochem. Physiol. B 143: 507-513.

Crockett, E.L. and R. L. Londraville. 2005.  Temperature.  In: The Physiology of Fishes 3rd Edition.  CRC Press.

Liu Q, and R. L. Londraville. 2003.  Using adult zebrafish visual system to study cadherin-2 expression during  central nervous system regeneration.  Methods Cell Sci. 00:1-8.

Tschantz, D.R., E.L. Crockett, P.H. Niewiarowski, and R.L. Londraville. 2002.  Cold acclimation strategy is highly  variable among the sunfishes (Centrarchidae)  Physiol. Biochem. Zool. 75:544-556.

R. L. Londraville and C.S. Duvall.  2002.  Murine leptin injections increase intracellular fat metabolism in green sunfish (Lepomis cyanellus)  Gen. and Comp Endocrin.  129:56-62.

Liu Q., R.L. Londraville, E. Azodi, S.G. Babb, C. Chiappini, J.A. Marrs, and P. A. Raymond. 2002.  Up-Regulation of Cadherin-2 and Cadherin-4 in Regenerating Visual Structures of Adult Zebrafish.  Experimental Neurology 177:396-406

R.L. Londraville, T. D. Cramer, J.P.C. Franck, A. Tullis, and B.A. Block. 2000.  Cloning of a neonatal calcium atpase isoform (SERCA 1B) from extraocular muscle of adult blue marlin (Makaira nigricans).  Comp. Biochem. Physiol. B 127:223-233.

Johnson, R.M.,  T.M. Johnson, and R.L. Londraville. 2000.  Evidence for leptin expression in fishes. J. Exp. Zool.  286(7):718-724

Niewiarowski, P.H., M.L. Balk, and R.L. Londraville. 2000. Murine leptin injection raises metabolic rate in an ectotherm. J. Exp. Biol.  203 (2):295-300

Crockett, E.L., R.L. Londraville, E.E. Wilkes, and M.C. Popesco. 1999. Enzymes from energy metabolism and fatty acid-binding protein in gill tissues from temperate and Antarctic fishes. J. Exp. Zool. 284(3):276-285.

Franck, J.P.C.F., J. Morrissette, J.E. Keen, R.L. Londraville, M. Beamsley, and B.A. Block. 1998. Cloning and characterization of fiber type-specific ryanodine receptor isoforms in skeletal muscles of fish. Am. J. Physiol. 275:C401-C415.

Vayda, M.E., R.L. Londraville, R.E. Cashon, L. Costello, and B.D. Sidell. 1998. Two distinct isoforms of fatty acid binding protein are expressed in heart ventricle of Antarctic teleost fishes. Biochem. J. 330(1):375-382.

Sidell, B.D., M.E. Vayda, D.J. Small, T.J. Moylan, R.L. Londraville, M.L. Yuan, K.J. Rodnick, Z.A. Eppley, and L. Costello. 1997. Variable expression of myoglobin among the hemoglobin- less Antarctic icefishes. Proc. Nat. Acad. Sci. 94:3420-3424. Link to abstract online

Londraville, R.L., and B.D. Sidell. 1996. Fatty acid-binding proteins in Antarctic fishes. Antarctic J. 30:177-179.

Londraville, R.L., and B.D. Sidell. 1996. Cold acclimation increases fatty acid-binding protein concentration in aerobic muscle of striped bass, Morone saxatilis. J. Exp. Zool. 275:36-44.

Londraville, R.L., J. Storch, and B.D. Sidell. 1996. Binding polarity and ligand affinity of homologous fatty acid-binding proteins from animals with different body temperatures. Mol. Cell. Biochem. 159: 39-45.

Londraville, R.L. 1996. Intracellular fatty acid-binding proteins: putting lower vertebrates in context. Braz. J. Med. Biol. Res. 29: 707-720. Link to article online

Londraville, R.L., and B.D. Sidell. 1995. Purification and characterization of fatty acid-binding protein from aerobic muscle of the Antarctic icefish Chaenocephalus aceratus. J. Exp. Zool. 273:190-203.

Londraville, R.L., and B.D. Sidell. 1990. Ultrastructure of aerobic muscle in Antarctic fishes may contribute to maintenance of diffusive fluxes. J. Exp. Biol. 150:205-220.

Londraville, R.L., and B.D. Sidell. 1990. A new method for estimating the maximal diffusion-distance for capillary supplied commodities within skeletal muscle. Respir. Physiol. 81:291-302.

Londraville, R.L. 1990. A courtship-like behavior pattern that can be used to identify the sex of a butterflyfish (Chaetodontidae). Copeia 1990:582-584.

Sidell, B.D., E.L. Crockett, R.L. Londraville, and E. Lund. 1989. Physiological and biochemical adaptations of Antarctic fish muscle to cold temperature. Antarctic. J. 24:198-200.


2021-24    NIH “Using Established Leptin Signaling Mutants to Study Cell Physiology and Bone Development in Zebrafish” $443,905 (RLL PI)

2020      UA Faculty Research Fellowships “Establishing Zebrafish as a Model for Leptin’s Effects on Bone” $10000 (RLL PI)

2015           UA Faculty Research Fellowships “Is This Why We are Fat? A Key Innovation in the Genome of Mammals” $10000 (RLL PI)

2012-15           NIH  “A Test of Leptin’s Central Function in Zebrafish” $435,000 (RLL PI)

2011-14           NIH  “Protocaderin 17 and 9 function in Retinal Development” $445,000 (RLL Co-PI)

2009-10           NIH ARRA Supplement “Research lab experience for Buchtel High School students” $14,500 (RLL PI)

2008-13           Ohio Board of Regents/Ohio Consortium for Bioinformatics/Choose Ohio First Scholarship Program $282000 (Duan PI, RLL Co-PI)

2008-11           NIH “Characterization of leptin’s effects in early developing and adult zebrafish” $220,500 (RLL PI, Q.Liu and B.Bagatto Co-PI’s)

2007-10           NIH “Cadherin 6 and -10 Function in the Retinal Ganglion and Amacrine Cell   Development” $220,500 (Q.Liu P.I., RLL Co-PI)

2007-8             Integrated Bioscience Program “Establishing a Proteomics Core” $7000

2001-04  NSF “Connecting Research and Teaching with Inquiry-Based Biology Laboratories” $99,979

2003-05  NSF “Proteomics as a Tool for Cloning Leptin from Fence Lizard Sceloperus undulatus” $80,019

2001-02 NSF, NSF “Isolating and Characterizing the fat-regulating hormone Leptin in the fence lizard”;, $80,000 Co-PI with Dr. Peter Niewiarowski.

2000-03 NIH,  “Leptin Structure and Function in Green Sunfish”; $134,500

2001       OBR    Ohio Board of Regents Research Challenge Award;  $20,000

1998-00 SeaGrant, “Development of a Non-Destructive Molecular Probe for Whole-Body Fat Stores in Largemouth Bass”; $89,974

1999 Spring Faculty Research Fellowship, Univ. of Akron; $5500

1999 Summer Teaching Academy Fellowship, Univ. of Akron, $4800

1999 Research Challenge II equipment grant, Univ. of Akron, $75,100

1998 Summer Faculty Research Fellowship, Univ. of Akron; $8000

1997 Summer Faculty Research Fellowship, Univ. of Akron; $6000


2019   “Most Valuable Professor” Award from Univ. Akron Men’s Soccer          Team

2012   Nominated for Faculty Mentor of the Year Award

2009    Project GRAD Honoree

2009    Nominated for Faculty Mentor of the Year Award

2007   Buchtel College of Arts and Sciences Service Award

2006     Top 2 ‘Best Practices” courses in Biology, Advanced Placement College Board, Center for Educational Policy Research, Eugene Oregon

2005     Outstanding Visiting Professor, Stone Laboratory, Ohio State University

2004     Ohio Magazine Excellence in Education Award

2004     Northeast Ohio Council on Higher Education Award for Teaching Excellence

2004     University of Akron Outstanding Teacher/Scholar Award

2003     Buchtel College of Arts and Sciences Teaching Award

modified 6/26/2020