Category Archives: Applied Science and Technology

Department of Defense Peer Reviewed Orthopaedic Research Program

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The FY20 Defense Appropriations Act provides funding to the Department of Defense Peer Reviewed Orthopaedic Research Program (PRORP) to support innovative, high-impact, clinically-relevant research to advance optimal treatment and rehabilitation from musculoskeletal injuries. As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency J9, Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test, and Evaluation (RDT&E) appropriation. The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP) at the U.S. Army Medical Research and Development Command (USAMRDC).

The FY20 PRORP Program Announcements and General Application Instructions for the following award mechanisms are posted on the Grants.gov website. 

Applications submitted to the FY20 PRORP must address one or more of the following FY20 Focus Areas:

  • Compartment Syndrome: Novel treatment strategies to improve current diagnoses for compartment syndrome. Alternatives to intracompartmental pressure measurements are encouraged.
  • Limb Stabilization and Protection: Development and/or clinical assessment of rapid limb stabilization and novel wound protectants for severely wounded limbs to enable transport at the point of need.
  • Orthotic Devices: Refinement of high-performance novel orthotic devices designed to enhance whole person performance and decrease pain in patients with limb salvage and impairment.
  • Osseointegration: Identification of best practices to address infection, rejection, and/or failure of percutaneous osseointegrated prosthetic limbs. 
  • Retention Strategies: Development, optimization, and/or validation of battlefield-feasible diagnostic capabilities, decision support tools, interventions, and/or rehabilitation strategies that can facilitate retention on duty for common combat-related musculoskeletal injuries.  Biomarker studies are excluded.  The current standard of care must be noted.  The rehabilitation strategy and the standard of care must be specified, as applicable.
    • Point of Injury: Battlefield-feasible strategies that can be utilized at or near the point of injury to allow an injured Service member to remain on duty and stay on mission without the need for immediate evacuation
    • Point of Duty: Strategies that can be utilized along the continuum of care to allow an injured Service member to return to duty without separation from Service.
  • Tissue Regeneration Therapeutics: Development of advanced tissue regeneration therapeutics in nerve, muscle (to include volumetric muscle loss), and/or composite tissue for the restoration of traumatically injured extremities.  Isolated bone or cartilage tissue engineering studies are excluded.
  • Translation of Early Findings: Translation of early research findings in the orthopaedic surgical care topic areas listed below to move the research toward clinical trials and clinical practice.
    • Soft Tissue Trauma: Strategies to develop and/or identify musculoskeletal extremity soft tissue trauma treatments for anterior cruciate ligament (ACL) or shoulder instability only, to optimize return to duty, work, or reintegration
    • Fracture-Related Infection: Strategies to decrease the burden of fracture-related infections (may include prevention, early detection, or improved eradication).  Alternatives to systemic and/or local antibiotic delivery are encouraged. 

https://cdmrp.army.mil/funding/prorp

Applied Research Award – Preproposal due May 27, 2020. Independent investigators at all academic levels (or equivalent):

  • Pre-application is required; full application submission is by invitation only.
  • Supports applied research applications focused on advancing optimal treatment and restoration of function for individuals with musculo-skeletal injuries sustained during combat or combat-related activities, and non-battle injuries that impact unit readiness and the ability to return to duty/work.
  • Proposed research should be supported by preliminary data and have the potential to make significant advancements toward clinical translation.
  • Clinical research and clinical trials are not allowed under this award mechanism.
  • Applications must address one of the following FY20 PRORP Focus Areas:
    • Limb Stabilization and Protection
    • Retention Strategies
      • Point of Injury
      • Return to Duty
  • Osseointegration

Maximum funding of $725,000 for total costs (includes direct and indirect costs). Maximum period of performance is 3 years.

Clinical Trial Award – Preproposal due May 27, 2020.Independent investigators at all academic levels (or equivalent):

  • Pre-application is required; full application submission is by invitation only.
  • Supports rapid implementation of clinical trials with the potential to have a major impact on military combat-related orthopaedic injuries or non-battle injuries that significantly impact unit readiness and return-to-duty/work rates.
  • Funding must support a clinical trial and may not be used for preclinical research studies.
  • Investigational New Drug or Investigational Device Exemption applications, if needed, should be submitted to the Food and Drug Administration within 6 months of the award date.
  • Applications must address one the following FY20 PRORP Focus Areas:
    • Limb Stabilization and Protection
    • Retention Strategies
      • Point of Injury
      • Return to Duty
    • Translation of Early Findings
      • Soft Tissue Trauma
      • Fracture-Related Infection

Funding Level 1:Maximum funding of $2.25M for total costs. (includes direct and indirect costs). Maximum period of performance is 4 years.

Funding Level 2 (Translation of Early Findings – Soft Tissue Trauma Focus Area with Rehabilitation Option): Maximum funding of $2.75M for total costs (includes direct and indirect costs). Maximum period of performance is 4 years.

Clinical Translational Research Award – Preproposal is due May 27, 2020. Independent investigators at all academic levels (or equivalent):

  • Pre-application is required; full application submission is by invitation only.
  • Supports high-impact and/or new/emerging clinical research that may or may not be ready for a full-scale, randomized, controlled clinical trial.
  • Funding must support clinical research studies involving humans.
  • Preliminary or published data relevant to the proposed research project are required.
  • Investigational New Drug or Investigational Device Exemption applications, if needed, should be submitted to the Food and Drug Administration within 12 months of the award date.
  • Applications must address one of the following FY19 PRORP CTRA Focus Areas:
    • Retention Strategies
      • Point of Injury
      • Return to Duty
    • Tissue Regeneration Therapeutics
    • Compartment Syndrome
    • Osseointegration
    • Orthotic Devices

Maximum funding of $1.5M for total costs (including direct and indirect costs). Maximum period of performance is 4 years.

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) prior to the pre-application deadline. All applications must conform to the final Program Announcements and General Application Instructions available for electronic downloading from the Grants.gov website. The application package containing the required forms for each award mechanism will also be found on Grants.gov. A listing of all CDMRP and other USAMRDC extramural funding opportunities can be obtained on the Grants.gov by performing a basic search using CFDA Number 12.420. 

For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage. For more information about the PRORP or other CDMRP-administered programs, please visit the CDMRP website.

Multidisciplinary Research Program of the University Research Initiative

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This FY 2021 Air Force Multidisciplinary Research Program of the University Research Initiative (MURI) competition is open only to, and proposals are to be submitted only by, US institutions of higher education (universities) with degree-granting programs in science and/or engineering, including DoD institutions of higher education. To the extent that it is a part of a US institution of higher education and is not designated as a Federally Funded Research and Development Center (FFRDC), a University Affiliated Research Center (UARC) or other University Affiliated Laboratory (UAL) is eligible to submit a proposal to this MURI competition and/or receive MURI funds. Ineligible organizations (e.g., industry, DoD laboratories, FFRDCs, and foreign entities) may collaborate on the research but may not receive MURI funds directly or via sub award. When additional funding for an ineligible organization is necessary to make the proposed collaboration possible, such funds may be identified via a separate proposal from that organization. This supplemental proposal shall be attached to the primary MURI proposal and will be evaluated in accordance with the MURI review criteria by the responsible Research Topic Chief. If approved, the supplemental proposal may be funded using non-MURI or non-Government funds.

DOD’s MURI program addresses high-risk basic research and attempts to understand or achieve something that has never been done before. The program was initiated over 25 years ago and it has regularly produced significant scientific breakthroughs with far reaching consequences to the fields of science, economic growth, and revolutionary new military technologies. Key to the program’s success is the close management of the MURI projects by Service program officers and their active role in providing research guidance.

Detailed descriptions of the topics and the Topic Chief for each can be found in Section II. I, entitled, “SPECIFIC MURI TOPICS,” (page 39 of 79 in the FOA document). The detailed descriptions are intended to provide the applicant a frame of reference and are not meant to be restrictive to the possible approaches to achieving the goals of the topic and the program. Innovative ideas addressing these research topics are highly encouraged.

HRSA Opioid-Impacted Family Support Program

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Announcement Number: HRSA-20-014

Bureau/Office: Bureau of Health Workforce

Date(s) to Apply: 01/21/2020 to 04/13/2020

Estimated Award Date: 09/01/2020

This program supports training programs that enhance and expand paraprofessionals knowledge, skills and expertise. It aims to increase the number of peer support specialists and other behavioral health-related paraprofessionals who work on interprofessional teams to provide services to children whose parents are impacted by opioid use disorders (OUD) and other substance use disorders (SUD), and their family members who are in guardianship roles.

There’s a special focus on demonstrating knowledge and understanding of the specific concerns for children, adolescents, and transitional aged youth in high need and high demand areas who are at risk for mental health disorders and SUDs.

Your organization is eligible if it is a state-licensed mental health nonprofit or for-profit organization. Your organization must be able to support programs for pre-service or in-service training of paraprofessional child, adolescent, and transitional aged youth mental health workers.

These training programs can include behavioral health-related paraprofessional occupations such as peer support specialist, peer support counselor, community health worker, outreach worker, behavioral health aide, social services aide, substance abuse/addictions worker, youth worker, and promotor/a (for full list of occupations see the Paraprofessional definition in section VIII of the NOFO).

For the purpose of this NOFO, organizations may include academic institutions (e.g. universities, community colleges and technical schools). They must be accredited by a nationally recognized accrediting agency, as specified by the U.S. Department of Education.

Domestic faith-based and community-based  organizations, tribes, and tribal organizations may apply for these funds, if otherwise eligible.

Individuals are not eligible to apply.

In addition to the 50 states, eligible entities include the District of Columbia, Guam, the Commonwealth of Puerto Rico, the Northern Mariana Islands, American Samoa, the U.S. Virgin Islands, the Federated States of Micronesia, the Republic of the Marshall Islands, and the Republic of Palau.

DARPA Defense Sciences Office BAA – Habitus for Cognitive Science, Computation & Defense

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This Broad Agency Announcement (BAA) constitutes a public notice of a competitive funding opportunity as described in Federal Acquisition Regulation (FAR) 6.102(d)(2) and 35.016 as well as 2 C.F.R. § 200.203. Any resultant negotiations and/or awards will follow all laws and regulations applicable to the specific award instrument(s) available under this BAA, e.g., FAR 15.4 for procurement contracts.

The Defense Sciences Office (DSO) at the Defense Advanced Research Projects Agency
(DARPA) is soliciting innovative research proposals to create self-sustaining, adaptive,
generalizable, and scalable methods for generating causal system models based on local
knowledge to aid operational decision making. Understanding how to work with and influence local systems to support stability operations is critical for operational decision making and is most challenging in undergoverned regions in which the systems themselves are often in flux or illegible. Establishing stability in such regions requires we facilitate actions that are in line with local views, yet our current means for understanding local systems such as the political, socioeconomic, and/or those related to health and infrastructure are limited.

Humans develop causal cognitive representations – or cognitive models – of systems of which they are a part. These models include factors (or variables), relationships among factors, and contexts that affect both. The knowledge behind these models is often hyper-localized, changing dramatically with regional and/or population dependent interactions of factors such as terrain, industries, population density (urban, rural), shared history, formal and informal power structures, religion, and ethnicity. These cognitive models, though often implicit, allow one to estimate which factors are most important for a given outcome and how those factors interact to anticipate future outcomes based on history, current events, and trends.

National Science Foundation PAPPG (NSF 20-1) Frequently Asked Questions

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The NSF has issued a set of Current and Pending Support Frequently Asked Questions (FAQs) that accompany the revised version of the NSF Proposal & Award Policies & Procedures Guide (PAPPG) (NSF 20-1), effective June 1, 2020. The FAQs address policy questions related to the PAPPG clarifications to the current and pending support coverage, as well as questions regarding use of an NSF-approved format for current and pending support. The FAQs will be updated periodically as appropriate.

If you have any questions regarding the 2020 PAPPG, please contact the DIAS/Policy Office by email at policy@nsf.gov