Program Solicitation: NSF 20-505

Full Proposal Deadline: Proposals accepted anytime

Synopsis of Program

The Division of Molecular and Cellular Biosciences (MCB) has developed a new opportunity to enable researchers with a strong track record of prior accomplishment to pursue a new avenue of research or inquiry. This funding mechanism is designed to facilitate and promote a PI’s ability to effectively adopt empowering technologies that might not be readily accessible in the PI’s current research environment or collaboration network. Transformative research likely spans disciplines and minimizing the practical barriers to doing so will strengthen research programs poised to make significant contributions. The award is intended to allow mid-career or later-stage researchers (Associate or Full Professor, or equivalent) to expand or make a transition in their research programs via a sabbatical leave or similar mechanism of professional development and then develop that research program in their own lab. This award will also enable the PI to acquire new scientific or technical expertise, facilitate the investigator’s competitiveness, and potentially lead to transformational impacts in molecular and cellular bioscience. The award would fund up to six months of PI salary during the first sabbatical or professional development year, followed by support for continued research for two subsequent years upon the PI’s return to normal academic duties. Through this solicitation MCB and NSF hope to develop a novel mechanism that will encourage investigators to expand and/or transition to new research areas aligned with MCB priorities, to increase retention of investigators in science, and to ensure a diverse scientific workforce that remains engaged in active research.

Through the “Transitions to Excellence In Molecular and Cellular Biosciences Research” (Transitions Award) program, MCB is seeking proposals that (1) promote fundamental understanding of complex living systems at the molecular, subcellular, and cellular levels typical of its core research programs and (2) enable investigators with a strong prior track record of accomplishment to expand or change research direction, thus ensuring their continued competitiveness in science.

Core research programs in MCB place a high priority on projects that provide mechanistic insights that can be used predictively to establish and verify the rules governing life’s processes. MCB encourages proposals that address major biological questions at the intersections of biology with other disciplines, such as physics, chemistry, mathematics, computer sciences, and engineering.

The following cross-cutting areas of research, most notably where they elucidate the rules governing life’s processes, will be given high priority for funding in all clusters in MCB core programs.

• Integrating Across Scales: Integrating knowledge from single molecules to molecular machines and from networks to subcellular and cellular complexity.
• Transformative Methods and Resources: Developing technologies for molecular and cellular biology research (when motivated by compelling biological questions), including biophysical and computational methods for broad application and genetic resources for model systems.
• Molecular and Cellular Evolution: Discovering mechanisms and theoretical underpinnings of evolutionary changes in molecules, genomes, and cells.
• Synthesizing Life-Like Systems: Using synthetic molecular parts and processes to understand the transition from simple to complex systems and to build novel living systems.
• Genomes to Phenomes: Integrating theoretical, computational, and high-throughput experimental approaches to determine and predict how the genome/epigenome gives rise to phenotype.