Dr. Bing Yu has been awarded a 3-year, $462,580 grant from the National Cancer Institute for his research project, entitled “Longitudinal assessment of tumor hypoxia in vivo using near-infrared spectroscopy.” The objective of this R15 grant is to develop a next generation frequency-domain near-infrared spectroscopy instrument for longitudinal assessment of tumor hypoxia and the efficacy of chemo-radiotherapy in orthotopic models of breast cancer. Tumor hypoxia (lack of oxygen) is an important characteristic of solid tumors and has been long recognized as a major catalyst in the development of tumor resistance to radiation and chemotherapy. Being able to noninvasively and cost-effectively quantify the temporal profile of tumor oxygenation in vivo will undoubtedly promote the development of optimized and individualized cancer therapy as well as advance our knowledge about tumor hypoxia. Dr. Yu is collaborating with Dr. Nicholas Denko, MD, in Radiation Oncology from OSUCCC-James in this project.