Researchers Develop Novel Method for Precise, Controllable Cell Deposition onto Tissue Engineering Constructs

Researchers Develop Novel Method for Precise, Controllable Cell Deposition onto Tissue Engineering Constructs

New Rochelle, NY, October 17, 2018—A new study presents a novel method of using a microfluidic flow cell array to achieve precise and reproducible control of cell deposition onto engineered tissue constructs to produce tunable cell patterns and generate essential integration zones. This microfluidic flow cell array cell deposition method, used to generate engineered musculoskeletal tissues, is described in an article in Tissue Engineering, Part C, Methods, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. Click here to read the full-text article free on the Tissue Engineering website through November 18, 2018.

David Ede, Alejandro Blitch, Niloofar Farhang, and Robby Bowles, University of Utah, and Nikki Davidoff, Carterra, describe how they use this new method to create stable integrating cell populations and controlled cell gradients in the article entitled “Microfluidic Flow Cell Array for Controlled Cell Deposition in Engineered Musculoskeletal Tissues.” They present the methods developed for deposition of human adipose derived stem cells and human osteoblasts using a 12-channel pilot printhead, and describe how microfluidic flow cell array cell deposition could be used to create an extensive variety of engineered musculoskeletal tissues.

“The described microfluidic method is an important step forward in the engineering of tissues, like cartilage and tendons, which need for their attachment to bone a fibrocartilaginous transition layer,” says Methods Co-Editor-in-Chief John A. Jansen, DDS, PhD, Professor and Head, Department of Biomaterials, Radboud University Medical Center, The Netherlands.

About the Journal
Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-in-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and John P. Fisher, PhD, Fischell Family Distinguished Professor & Department Chair, and Director of the NIH Center for Engineering Complex Tissues at the University of Maryland, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Leadership of Tissue Engineering Parts B (Reviews) and Part C (Methods) is provided by Katja Schenke-Layland, PhD, Eberhard Karls University, Tübingen and John A. Jansen, DDS, PhD, Radboud University, respectively. Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed on the Tissue Engineering website.

About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.

DoD Amyotrophic Lateral Sclerosis Research Program Pre-announcement

Defense Health Program
Department of Defense Amyotrophic Lateral Sclerosis Research Program

Anticipated Funding Opportunities for Fiscal Year 2019 (FY19)

 

The FY19 Defense Appropriations Act provides $10 million (M) to the Department of Defense Amyotrophic Lateral Sclerosis Research Program (ALSRP) to support innovative and high-impact research into preclinical development of therapeutics for Amyotrophic Lateral Sclerosis.  As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency (DHA), J9 Research and Development Directorate manages the Defense Health Program (DHP) Research, Development, Test and Evaluation (RDT&E) appropriation.  The managing agent for the anticipated Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs (CDMRP).

The ALSRP is providing the information in this pre-announcement to allow investigators time to plan and develop applications.  FY19 ALSRP Program Announcements and General Application Instructions for the following award mechanisms are anticipated to be posted on the Grants.gov website in November 2018.  Pre-application and application deadlines will be available when the Program Announcements are released.  This pre-announcement should not be construed as an obligation by the government.

The mission of the ALSRP is to fund innovative preclinical research to develop new treatments for ALS for the benefit of Service members, Veterans, and the general public.

http://cdmrp.army.mil/pubs/press/2019/19alsrppreann

The following mechanisms are planned for release:

Therapeutic Development Award

  • Independent investigators at all academic levels
  • Pre-application is required; full application submission is by invitation only
  • Supports post-discovery, preclinical advancement of therapeutics for ALS
  • Preliminary data, including identity and purity of an identified bioactive compound(s), are required
  • Clinical trials are not allowed
  • Types of efforts that will be supported include:
    • Confirmation of candidate therapeutics obtained from screening or by other means
    • Validation of early pilot studies in multiple model systems and/or replicating preliminary data with more time points or additional doses
    • Optimization of potency and pharmacology, studies of formulation, stability, and production methods based on Good Manufacturing Practices
    • Investigational New Drug-enabling studies
    • Optional Therapeutic Relevance Option: Applications proposing development of markers to improve the drug development process in parallel with the main therapeutic advancement effort and that meet the criteria outlined in the Program Announcement/Funding Opportunity will qualify for a higher level of funding
  • Maximum funding of $1,000,000 for direct costs (plus indirect costs)
  • If applying for the Therapeutic Relevance Option, the maximum funding is $1,250,000 for direct costs (plus indirect costs)
  • Maximum period of performance is years

 

Therapeutic Idea Award

  • Independent investigators at all academic levels
  • Pre-application is required; full application submission is by invitation only
  • Supports new ideas aimed at drug or treatment discovery that are still in the early stages of development
  • Preliminary data are not required
  • Types of efforts that will be supported include:
    • Exploitation of pathways known to be relevant to ALS for the purpose of improving treatment and/or advancing a novel treatment modality
    • Development, modification, and use of high-throughput screens and novel model systems to define or assess lead compounds
  • Projects that focus primarily on investigating the pathophysiology of ALS are outside the scope of this award mechanism
  • Maximum funding of $500,000 for direct costs (plus indirect costs)
  • Maximum period of performance is years

 

A pre-application is required and must be submitted through the electronic Biomedical Research Application Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline.  All applications must conform to the final Program Announcements and General Application Instructions that will be available for electronic downloading from the Grants.gov website.  The application package containing the required forms for each award mechanism will also be found on Grants.gov.  A listing of all CDMRP funding opportunities can be obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.

 

Applications must be submitted through the federal government’s single-entry portal, Grants.gov.  Submission deadlines are not available until the Program Announcements are released.  For email notification when Program Announcements are released, subscribe to program-specific news and updates under “Email Subscriptions” on the eBRAP homepage at https://eBRAP.org.  For more information about the ALSRP or other CDMRP-administered programs, please visit the CDMRP website (http://cdmrp.army.mil).

 

Point of Contact:

CDMRP Public Affairs
301-619-9783
usarmy.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@mail.mil

Book mark the CDMRP website:

cdmrp.army.mil

 

Follow CDMRP on Twitter at:

twitter.com/CDMRP

View CDMRP research results on YouTube:

www.youtube.com/user/CDMRP

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NIH Data Sharing, Sexual Harassment, Loan Repayment, Grant Videos and more

NIH Policies to Address Sexual and Gender Harassment in NIH-supported Extramural Research

Several months ago, we learned in the press that an NIH-supported investigator was banned from his university campus pending an ongoing investigation into allegations of sexual misconduct. The institution, which was the recipient of the awards in which this investigator was designated as principal investigator (PI), had not informed us of this situation. Once aware, we contacted senior institutional officials to discuss the need to ensure the effective stewardship of the award under these circumstances. We requested that the institution provide us with alternative plans for conducting the research given that this individual would no longer serve as PI and would have no other involvement in the NIH-funded research, and we reminded them (as we recently reminded the community and as reiterated below) that they are responsible for notifying NIH of any change in status that might affect the ability of an individual identified as key personnel to conduct NIH-supported research. Continue reading →

NIH Loan Repayment Programs: A Lifeline for Biomedical and Biobehavioral Researchers: Applications Accepted September 1 – November 15

By the time many researchers have completed their education and training, they have amassed on average $160,000 in student loan debt. The NIH Loan Repayment Programs (LRPs) are a set of programs established by Congress and designed to recruit and retain highly qualified health professionals into biomedical or biobehavioral research careers. The LRPs counteract early-career researchers’ financial pressure by repaying up to $35,000 annually ($70,000 over a two-year contract) of a researcher’s qualifying educational debt in return for a commitment to engage in research areas important to the mission of NIH. Continue reading →

 

A Data Sharing Renaissance: Music to My Ears!

Guest post by Carrie Wolinetz P.h.D., NIH Associate Director for Science Policy

When world famous cellist, Yo-Yo Ma, visited the NIH campus, he shared a story from the history of music, in which the peak of stringed instrument quality occurred in the late 17th century at a time of great collaboration and sharing of knowledge. When instrument makers began to compete, all of that changed: secrets of craftsmanship were held close and the quality of instruments plummeted. This decline lasted, according to Ma, until the 20th century, when again the free-flow of knowledge resumed. NIH Director Francis Collins noted, “There’s a lesson here about science.”
Continue reading →

Top Stories

The Roles of Fellows and Trainees in NIH Supported Clinical Trials

Posted by Staff from the Division of Biomedical Research Workforce

NIH encourages fellows supported on NIH NRSA Fellowship awards and trainees supported on NIH NRSA Training awards to receive training in clinical research, including in the conduct of clinical trials. Under a mentor’s guidance, fellows and trainees can gain experience in the wide variety of research skills specific to clinical trials including, but not limited to: developing a clinical trial protocol; applying the principles of informed consent and requirements for human subjects research; learning about random assignment of participants to different intervention arms; analyzing trial endpoints; and/or implementing quality control standards. Continue reading →

Join Us for the 20th Anniversary of the HHS SBIR/STTR Conference in Dallas, TX!

This dynamic, national, three-day event is designed to educate attendees about America’s Largest Seed Fund and how to access federal resources, develop competitive proposals, and secure awards.  At $1 billion dollars of annual HHS funding, this is one of the largest sources of early-stage capital for life science technology commercialization in the United States. Hosted by the Dallas Regional Chamber, A Better Tomorrow: Big Ideas in BioTech will be relevant to a diverse audience, including biomedical entrepreneurs; principal investigators; grants and contracts administrators; and industry partners and investors. Continue reading →

 

Resources

 

Your Grant Application Questions Answered in New NIH Center for Scientific Review Videos

Curious about how NIH grant applications are reviewed? Get a front row seat to the peer review process in this video created by the NIH Center for Scientific Review (CSR). Investigators will get insights into how applications are reviewed so they can better enhance and advance their applications in the NIH peer review process. Continue reading →

 

New Grant Application Submission Tips for Success Videos

Getting ready to apply for a grant and don’t know where to start? Set yourself up for success with tips from the experts at NIH. Quickly learn how to access application forms, ensure your application is a good fit for an announcement, and make an important final check of your application after submitting with new videos from the Office of Extramural Research (OER). Continue reading →

 

Archived Protecting Human Research Participants (PHRP) Training and Alternative Courses Reminder

As announced in our previous blog post and policy notice, as of September 26, 2018, NIH is no longer able to offer its Protecting Human Research Participants (PHRP) course and does not plan to provide an alternative course. Although similar courses are available elsewhere, such courses are not affiliated with or endorsed by NIH. Continue reading →

NIH Online Clinical Research Courses are Now Open

Want to gain knowledge in clinical research and pharmacology? Start learning now through the FREE self-paced courses offered by the NIH Office of Clinical Research. Continue reading →

New Grant Application Tips for Success Videos

New Grant Application Tips for Success Videos

by NIH Staff

Getting ready to apply for a grant and don’t know where to start? Set yourself up for success with tips from the experts at NIH. Quickly learn how to access application forms, ensure your application is a good fit for an announcement, and make an important final check of your application after submitting with new videos from the Office of Extramural Research (OER).

Check out these helpful quick tip videos on the How to Apply – Video Tutorials page to help you avoid common mistakes and position yourself for success:

NIH Staff | October 12, 2018 at 10:43 am | URL: https://wp.me/p7Dr3j-4NM

Call for Biomedical Project Proposals

Would your research benefit from the involvement of thousands of volunteers? We are currently seeking proposals for biomedical projects to be developed as part of the Zooniverse platform. The Zooniverse is the world’s largest and most successful online platform for crowd-sourced research; we currently have over 1.5 million registered volunteers working in collaboration with professional researchers on more than 50 research projects across a range of disciplines, from physics to biology.

Using our unique Project Builder you can create your own Zooniverse project for free with a set of tried and tested tools, including multiple-choice questions and region marking or drawing tools. If we don’t yet offer the tools you need, please propose your project below; we are particularly interested in developing novel projects that extend the functionality of our platform.

Project Selection

We are looking for biomedical projects that will help us expand the functionality of the Zooniverse and build on the selection of tools available to researchers via our platform. Projects may involve a processing task applied to images, graphs, videos or another data format, data collection, or a combination of the two. Successful projects will be developed and hosted by the Zooniverse team, in close collaboration with the applicants.

Examples of our current biomedical projects include Microscopy Masters, where volunteers classify cryo-electron microscopy images to advance understanding of protein and virus structure, and Worm Watch Lab, which aims to improve understanding of the relationship between genes and behaviour.

Selection Criteria:

  1. Projects extending the capability of the Zooniverse platform or serving as case studies for crowdsourcing in new areas are encouraged.
  1. Alignment with biomedical research (long-term aim of research is to improve human health outcomes).
  1. Merit and usefulness of the data expected to result from the project.

Deadline

Project proposals are accepted on a rolling basis. Applications will be reviewed at the beginning of each month.

SUBMIT A BIOMEDICAL PROPOSAL

https://www.zooniverse.org/get-involved/call-for-projects

______________________________________________________________________

About

AboutPublicationsOur TeamAcknowledgementsResourcesContact UsFAQ

What is the Zooniverse?

The Zooniverse is the world’s largest and most popular platform for people-powered research. This research is made possible by volunteers — hundreds of thousands of people around the world who come together to assist professional researchers. Our goal is to enable research that would not be possible, or practical, otherwise. Zooniverse research results in new discoveries, datasets useful to the wider research community, and many publications.

At the Zooniverse, anyone can be a researcher

You don’t need any specialised background, training, or expertise to participate in any Zooniverse projects. We make it easy for anyone to contribute to real academic research, on their own computer, at their own convenience.

You’ll be able to study authentic objects of interest gathered by researchers, like images of faraway galaxies, historical records and diaries, or videos of animals in their natural habitats. By answering simple questions about them, you’ll help contribute to our understanding of our world, our history, our Universe, and more.

With our wide-ranging and ever-expanding suite of projects, covering many disciplines and topics across the sciences and humanities, there’s a place for anyone and everyone to explore, learn and have fun in the Zooniverse. To volunteer with us, just go to the Projects page, choose one you like the look of, and get started.

We accelerate important research by working together

The major challenge of 21st century research is dealing with the flood of information we can now collect about the world around us. Computers can help, but in many fields the human ability for pattern recognition — and our ability to be surprised — makes us superior. With the help of Zooniverse volunteers, researchers can analyze their information more quickly and accurately than would otherwise be possible, saving time and resources, advancing the ability of computers to do the same tasks, and leading to faster progress and understanding of the world, getting to exciting results more quickly.

Our projects combine contributions from many individual volunteers, relying on a version of the ‘wisdom of crowds’ to produce reliable and accurate data. By having many people look at the data we often can also estimate how likely we are to make an error. The product of a Zooniverse projects is often exactly what’s needed to make progress in many fields of research.

Volunteers and professionals make real discoveries together

Zooniverse projects are constructed with the aim of converting volunteers’ efforts into measurable results. These projects have produced a large number of published research papers, as well as several open-source sets of analyzed data. In some cases, Zooniverse volunteers have even made completely unexpected and scientifically significant discoveries.

A significant amount of this research takes place on the Zooniverse discussion boards, where volunteers can work together with each other and with the research teams. These boards are integrated with each project to allow for everything from quick hashtagging to in-depth collaborative analysis. There is also a central Zooniverse board for general chat and discussion about Zooniverse-wide matters.

Many of the most interesting discoveries from Zooniverse projects have come from discussion between volunteers and researchers. We encourage all users to join the conversation on the discussion boards for more in-depth participation.

https://www.zooniverse.org/about